High Molecular Weight Kininogen: A Review of the Structural Literature.
Int J Mol Sci
; 22(24)2021 Dec 13.
Article
in English
| MEDLINE | ID: covidwho-1597050
ABSTRACT
Kininogens are multidomain glycoproteins found in the blood of most vertebrates. High molecular weight kininogen demonstrate both carrier and co-factor activity as part of the intrinsic pathway of coagulation, leading to thrombin generation. Kininogens are the source of the vasoactive nonapeptide bradykinin. To date, attempts to crystallize kininogen have failed, and very little is known about the shape of kininogen at an atomic level. New advancements in the field of cryo-electron microscopy (cryoEM) have enabled researchers to crack the structure of proteins that has been refractory to traditional crystallography techniques. High molecular weight kininogen is a good candidate for structural investigation by cryoEM. The goal of this review is to summarize the findings of kininogen structural studies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Kininogen, High-Molecular-Weight
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Ijms222413370
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