Your browser doesn't support javascript.
Isolation and pathogenic characterization of duck adenovirus 3 mutant circulating in China.
Shi, Xinjin; Zhang, Xinyu; Sun, Haiwei; Wei, Changqing; Liu, Yingnan; Luo, Jiguan; Wang, Xuebo; Chen, Zongyan; Chen, Hongjun.
  • Shi X; Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
  • Zhang X; College of Veterinary Medicine, Yangzhou University, Yangzhou, 200295, China.
  • Sun H; Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
  • Wei C; Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
  • Liu Y; Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
  • Luo J; Shandong Sinder Biotechnology Company, Zhucheng, 262200 China.
  • Wang X; Shandong Sinder Biotechnology Company, Zhucheng, 262200 China.
  • Chen Z; Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China. Electronic address: zychen@shvri.ac.cn.
  • Chen H; Shanghai Veterinary Research Institute, CAAS, Shanghai 200241, China.
Poult Sci ; 101(1): 101564, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1598044
ABSTRACT
Duck adenoviruses (DAdVs) include serotype 1 (DAdV-1) in the genus Atadenovirus and serotypes 2-4 (DAdV-2, 3, and 4) in the genus Aviadenovirus. DAdV-3 was initially isolated from Chinese Muscovy ducks in 2014, whereby the infected ducks exhibited yellowing and hemorrhaging in the liver, along with slight pericardial effusion, swelling, and hemorrhaging in the kidneys. In recent years, duck adenovirus infections have appeared in Muscovy duck farms in Fujian, Zhejiang, Anhui, Guangdong, and other places in China. They have an incidence rate of 40 to 55% and a mortality rate of 35 to 43%, resulting in great losses to the duck breeding industry. In this study, 7 DAdV-3 strains, designated as TZ193, FJPT20161124, GX20170519, FJZZ, GDMM, AHAQ, and GDHS were isolated from Muscovy ducks in different provinces of China during 2016-2019, and their complete genomics were sequenced. Their genomes all exhibited significant deletions in ORF67, which also had G to A transitions at the 41st and 977th nt positions, resulting in a stop codon. The pathogenicity of TZ193, a novel isolate of DAdV-3, was investigated in Muscovy ducks. TZ193 caused characteristic lesions of swelling as well as hemorrhagic liver and kidney in the infected ducklings. Moreover, the mortality rate of TZ193 in 5-day-old domestic ducks was 100%. Our data provide concrete evidence for the identification of the DAdV-3 novel variant mutant in China, which effects increased mortality in ducks. This highlights the necessity for monitoring the specific molecular epidemiology of novel DAdV-3 mutants and the development of new vaccines in the future.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Aviadenovirus / Ducks Type of study: Observational study Topics: Vaccines / Variants Limits: Animals Country/Region as subject: Asia Language: English Journal: Poult Sci Year: 2022 Document Type: Article Affiliation country: J.psj.2021.101564

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Aviadenovirus / Ducks Type of study: Observational study Topics: Vaccines / Variants Limits: Animals Country/Region as subject: Asia Language: English Journal: Poult Sci Year: 2022 Document Type: Article Affiliation country: J.psj.2021.101564