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Adolescent THC Treatment Does Not Potentiate the Behavioral Effects in Adulthood of Maternal Immune Activation.
Stollenwerk, Todd M; Hillard, Cecilia J.
  • Stollenwerk TM; Neuroscience Research Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Wauwatosa, WI 53226, USA.
  • Hillard CJ; Neuroscience Research Center, Department of Pharmacology and Toxicology, Medical College of Wisconsin, Wauwatosa, WI 53226, USA.
Cells ; 10(12)2021 12 11.
Article in English | MEDLINE | ID: covidwho-1598389
ABSTRACT
Both in utero exposure to maternal immune activation and cannabis use during adolescence have been associated with increased risk for the development of schizophrenia; however, whether these exposures exert synergistic effects on brain function is not known. In the present study, mild maternal immune activation (MIA) was elicited in mice with prenatal exposure to polyinosinic-polycytidylic acid (poly(IC)), and ∆9-tetrahydrocannabinol (THC) was provided throughout adolescence in cereal (3 mg/kg/day for 5 days). Neither THC nor MIA pretreatments altered activity in assays used to characterize hyperdopaminergic states in adulthood amphetamine hyperlocomotion and prepulse inhibition of the acoustic startle reflex. Adolescent THC treatment elicited deficits in spatial memory and enhanced spatial reversal learning in adult female mice in the Morris water maze, while exposure to MIA elicited female-specific deficits in fear extinction learning in adulthood. There were no effects in these assays in adult males, nor were there interactions between THC and MIA in adult females. While doses of poly(IC) and THC were sufficient to elicit behavioral effects, particularly relating to cognitive performance in females, there was no evidence that adolescent THC exposure synergized with the risk imposed by MIA to worsen behavioral outcomes in adult mice of either sex.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Dronabinol / Behavior, Animal / Aging Type of study: Experimental Studies / Prognostic study Limits: Animals / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Cells10123503

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Prenatal Exposure Delayed Effects / Dronabinol / Behavior, Animal / Aging Type of study: Experimental Studies / Prognostic study Limits: Animals / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Cells10123503