Your browser doesn't support javascript.
Self-administered oral glucose tolerance test with capillary glucose measurements for the screening of diabetes mellitus in high-risk adults: a feasibility study.
Tan, Andrew Yen Siong; Tan, Mui Suan; Wu, Ashley; Seah, Ai Choo; Chong, Cecilia; Koh, Eileen; Tan, Ngiap Chuan.
  • Tan AYS; SingHealth Polyclinics, Singapore andrew.tan.y.s@singhealth.com.sg.
  • Tan MS; SingHealth Polyclinics, Singapore.
  • Wu A; Family Medicine Academic Clinical Program, SingHealth Duke-NUS Academic Medical Centre, Singapore.
  • Seah AC; SingHealth Polyclinics, Singapore.
  • Chong C; SingHealth Polyclinics, Singapore.
  • Koh E; SingHealth Polyclinics, Singapore.
  • Tan NC; SingHealth Polyclinics, Singapore.
BMJ Open Diabetes Res Care ; 9(2)2021 12.
Article in English | MEDLINE | ID: covidwho-1598547
ABSTRACT

INTRODUCTION:

Early diagnosis of prediabetes based on blood sampling for the oral glucose tolerance test (OGTT) is crucial for intervention but multiple barriers hinder its uptake. This study aimed to assess the feasibility and precision of a self-administered capillary OGTT for type-2 diabetes mellitus (T2DM) in high-risk individuals. RESEARCH DESIGN AND

METHODS:

Participants with history of gestational diabetes or prediabetes were recruited in primary care. Due to their prediabetic status and previous diagnosis of gestational diabetes mellitus, a proportion of participants had previous experience doing OGTT. They self-administered the capillary OGTT and concurrently their venous glucose samples were obtained. They filled a questionnaire to collect their demographic information, views of their capillary OGTT, and their preferred site of the test.

RESULTS:

Among 30 participants enrolled in this feasibility study, 93.3% of them felt confident of performing the capillary OGTT themselves, and 70.0% preferred the test at home. Older, less educated participants found it less acceptable. Mean capillary glucose values were significantly higher than venous glucose values, with mean difference at 0.31 mmol/L (95% CI 0.13 to 0.49) at fasting, and 0.47 mmol/L (95% CI 0.12 to 0.92) 2 hours post-OGTT. Capillary and venous glucose measurements were correlated for fasting (r=0.95; p<0.001) and 2-hour-post-OGTT (r=0.95;p<0.001). The Fleiss-Kappa Score (0.79, p<0.0001) indicated fair agreement between the two methods. The capillary OGTT had excellent sensitivity (94.1%) and negative predictive value (NPV=91.7%) in identifying prediabetes or T2DM status, vis-a-vis to venous glucose samples.

CONCLUSION:

Self-administered capillary OGTT is feasible and acceptable, especially among younger adults, with excellent sensitivity and NPV compared with plasma-based OGTT.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Prediabetic State / Diabetes, Gestational Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors / Screening study Limits: Adult / Female / Humans / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Bmjdrc-2021-002556

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Prediabetic State / Diabetes, Gestational Type of study: Diagnostic study / Etiology study / Prognostic study / Risk factors / Screening study Limits: Adult / Female / Humans / Pregnancy Language: English Year: 2021 Document Type: Article Affiliation country: Bmjdrc-2021-002556