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Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines.
Tuli, Hardeep Singh; Sak, Katrin; Aggarwal, Poonam; Iqubal, Ashif; Upadhaya, Sushil K; Kaur, Jagjit; Kaur, Ginpreet; Aggarwal, Diwakar.
  • Tuli HS; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, India.
  • Sak K; Non-Governmental Organization (NGO) Praeventio, Tartu, Estonia.
  • Aggarwal P; The Basic Research Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, United States.
  • Iqubal A; Department of Pharmacology, School of Pharmaceutical Education and Research (Formerly Faculty of Pharmacy), Jamia Hamdard (Deemed to be University), Delhi, India.
  • Upadhaya SK; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, India.
  • Kaur J; Graduate School of Biomedical Engineering, ARC Centre of Excellence in Nanoscale BioPhotonics (CNBP), Faculty of Engineering, The University of New South Wales, Sydney, NSW, Australia.
  • Kaur G; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal, Narsee Monjee Institute of Management Studies (SVKM'S NMIMS), Mumbai, India.
  • Aggarwal D; Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana, India.
Front Cell Infect Microbiol ; 11: 763687, 2021.
Article in English | MEDLINE | ID: covidwho-1598820
ABSTRACT
Within almost the last 2 years, the world has been shaken by the coronavirus disease 2019 (COVID-19) pandemic, which has affected the lives of all people. With nearly 4.92 million deaths by October 19, 2021, and serious health damages in millions of people, COVID-19 has been the most serious global challenge after the Second World War. Besides lost lives and long-term health problems, devastating impact on economics, education, and culture will probably leave a lasting impression on the future. Therefore, the actual extent of losses will become obvious only after years. Moreover, despite the availability of different vaccines and vaccination programs, it is still impossible to forecast what the next steps of the virus are or how near we are to the end of the pandemic. In this article, the route of molecular evolution of the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thoroughly compiled, highlighting the changes that the virus has undergone during the last 2 years and discussing the approaches that the medical community has undertaken in the fight against virus-induced damages.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pharmaceutical Preparations / Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.763687

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pharmaceutical Preparations / Vaccines / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.763687