Host Genetic Liability for Severe COVID-19 Associates with Alcohol Drinking Behavior and Diabetic Outcomes in Participants of European Descent.
Front Genet
; 12: 765247, 2021.
Article
in English
| MEDLINE | ID: covidwho-1599197
ABSTRACT
Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use (genetic causality proportion (gcp) with severe respiratory COVID-19 = 0.576, p = 1.07 × 10-5 and hospitalized COVID-19 = 0.713, p = 0.003), and alcohol drinking status (gcp with severe respiratory COVID-19 = 0.633, p = 7.04 × 10-5 and hospitalized COVID-19 = 0.848, p = 4.13 × 10-13). COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors and potential long-term health effects of severe response to infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Topics:
Long Covid
Language:
English
Journal:
Front Genet
Year:
2021
Document Type:
Article
Affiliation country:
Fgene.2021.765247
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