Serum Krebs von den Lungen-6 for Predicting the Severity of COVID-19 Lung Injury: A Systematic Review and Meta-Analysis.
Iran Biomed J
; 25(6): 381-9, 2021 11 01.
Article
in English
| MEDLINE | ID: covidwho-1599259
ABSTRACT
Background:
Lung injury is common in coronavirus disease 2019 (COVID-19) patients. The severity of lung injury appears to be reflected in serum Krebs von den Lungen-6 (KL-6), a glycoprotein expressed on type II alveolar epithelium. This study aims to assess the role of serum KL-6 in reflecting the severity of lung injury in COVID-19 patients.Methods:
A systematic search was conducted in Scopus, PubMed, Wiley Online Library, and ProQuest. Articles were screened based on several eligibility criteria and assessed for study quality using Newcastle-Ottawa Scale.Results:
This systematic review included four studies involving a total of 151 adult COVID-19 patients. Pooled analysis revealed that serum KL-6 was significantly higher in severe patients (SMD = 1.16; 95% CI = 0.691.63) with moderately high pooled sensitivity (79%; 95% CI = 6191%) and specificity (86%; 95% CI = 7295%).Conclusion:
High serum KL-6 may depict more severe lung injury in COVID-19 patients with moderately high sensitivity and specificity.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severity of Illness Index
/
Mucin-1
/
Lung Injury
/
COVID-19
Type of study:
Diagnostic study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Iran Biomed J
Journal subject:
Biology
/
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Ibj.25.6.381
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