Mortality in Patients of COVID-19 Infection: Biochemical Markers and its Cut-off Values for Predicting Outcome.
J Coll Physicians Surg Pak
; 32(1): 37-41, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1599461
ABSTRACT
OBJECTIVE:
To determine the efficacy and cut-off values of C-reactive protein (CRP), lactate dehydrogenase (LDH), serum ferritin, and D-dimer for predicting mortality of COVID-19 infection. STUDYDESIGN:
Observational study. PLACE AND DURATION OF STUDY Department of Medicine, Jinnah Hospital, Lahore from January to May 2021.METHODOLOGY:
Serum CRP, LDH, ferritin, and D-dimer were measured in patients with moderate to severe COVID-19 infection at admission. Patients were followed for in-hospital disease outcome. ROC curve was used to determine area under curve (AUC) and cut-off values of biomarkers, followed by multi-variate analysis by logistic regression.RESULTS:
In 386 patients, male to female ratio was 1.47/1 (230/156); and mean age was 54.03 ± 16.2 years. Disease was fatal in 135 (35%) patients. AUC for mortality was 0.730 for LDH, 0.737 for CRP, 0.747 for ferritin and 0.758 for D-dimer. Mortality was higher with LDH ≥400 U/ml, Odds Ratio (OR) 5.37 (95% CI 3.01-9.57 p = 0.001), CRP ≥30 ng/L, OR 4.30 (95% CI 2.11-8.74 p = <0.001), serum ferritin ≥200 ng/ml, OR 4.13 (95% CI 1.05-16.2 p = 0.02), and D-dimer ≥400 ng/ml, OR 2.72 (95% CI 1.06-7.01 p = 0.03) with 2 log likelihood of 131.54 for predicting disease outcome with 71.7% accuracy in multi-variate analysis.CONCLUSION:
Elevated serum CRP, LDH, ferritin and D-dimer are associated with higher mortality in patients of COVID-19 infection. Serum CRP ≥30ng/ml, LDH ≥400 U/L, ferritin ≥200 ng/ml and D-dimer ≥400 ng/ml can predict fatal outcome in COVID-19 patients. Key Words C-reactive protein (CRP), COVID-19 infection, D-dimer, Ferritin, Lactate dehydrogenase (LDH), Mortality.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biomarkers
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Coll Physicians Surg Pak
Journal subject:
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
Jcpsp.2022.01.37
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