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[A randomized controlled trial study of immunogenicity and safety of an inactivated SARS-CoV-2 vaccine in different immunization schedules].
Chen, J; Li, X Q; Lu, X X; Xing, R Q; Li, H; Zhang, X H; Wei, Z Y; Mu, S C; Feng, L Z; Wang, S P.
  • Chen J; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Li XQ; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Lu XX; School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
  • Xing RQ; Shanxi Aviation Industry Group Co., LTD, Taiyuan 030031, China.
  • Li H; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Zhang XH; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Wei ZY; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Mu SC; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Feng LZ; Shanxi Provincial Center for Disease Control and Prevention, Taiyuan 030012, China.
  • Wang SP; School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(12): 2077-2081, 2021 Dec 10.
Article in Chinese | MEDLINE | ID: covidwho-1600024
ABSTRACT

Objective:

To compare the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine used for the vaccination in public security officers with different immunization schedules.

Methods:

From January to February, 2021, 405 public security officers in Taiyuan were randomly divided into 3 groups. Two doses of SARS-CoV-2 inactivated vaccine were injected according to the immunization schedule of 0-14 days, 0-21 days or 0-28 days, respectively. The nucleic acid of SARS-CoV-2 was detected by reverse transcription polymerase chain reaction. The neutralizing antibodies to SARS-CoV-2 were tested by microdose cytopathogenic efficiency assay of live virus. The GMT, seroconversion rate of SARS-CoV-2 neutralizing antibody and safety of the vaccine were analyzed for the 3 groups.

Results:

The seroconversion rate of SARS-CoV-2 neutralizing antibody was 100% in all the 3 groups. The SARS-CoV-2 neutralizing antibody level of 0-21 day group [166.70 (95%CI 148.30-185.10)] was similar to that of 0-28 day group [179.50 (95%CI 156.50-202.60)] (P>0.05), significantly higher than that of 0-14 day group [86.08 (95%CI 72.36-99.80)] (P<0.001). The incidence rates of adverse reaction in the 3 groups were 1.48% (2/135), 0.74% (1/136) and 1.49% (2/134) respectively (P=0.750), all the adverse reactions were mild.

Conclusions:

The vaccination of inactivated SARS-CoV-2 vaccine with different immunization schedules in public security officers showed good safety and high seroconversion rate, and the GMTs of SARS-CoV-2 neutralizing antibody in 0-21 day group and 0-28 day group were higher than that in 0-14 day group.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: Chinese Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2021 Document Type: Article Affiliation country: Cma.j.cn112338-20210807-00617

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: Chinese Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2021 Document Type: Article Affiliation country: Cma.j.cn112338-20210807-00617