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Effects of SARS‑CoV‑2 on testicular function
Medical Journal of Wuhan University ; 43(1):1-5, 2022.
Article in Chinese | Scopus | ID: covidwho-1600038
ABSTRACT

Objective:

To describe the clinical characteristics of the male reproductive system of COVID‑19 patients and to explore the presence of SARS‑CoV‑2 in semen.

Methods:

Case series of 112 male patients with confirmed COVID‑19 who were admitted to Renmin Hospital of Wuhan University from January to March, 2020. Demographic data, symptoms and signs related to the male reproductive system, throat swabs and semen samples were collected and analyzed. SARS‑CoV‑2 RNA levels were measured in throat swab and semen samples. The organ distribution of ACE2 mRNA and protein in human tissue on HPA database were investigated.

Results:

The HPA dataset revealed relatively high levels of ACE2 protein and RNA expression in testis. A total of 3 severe COVID‑19 patients (2.7%) presented with orchidoptosis, while no patient experienced other symptoms or signs related to the male reproductive system. The analysis of SARS‑CoV‑2 RNA in semen included 17 patients with fertility needs. In the semen SARS‑CoV‑2 analysis, all 17 patients were negative for the N gene and ORF1ab gene.

Conclusion:

The online datasets indicated the potential impairment of the testicular function by SARS‑CoV‑2. However, this study suggestes that male patients have few reproductive symptoms and signs, and SARS‑CoV‑2 was not present in the semen of patients with confirmed COVID‑19. In view of the potential impairment, the long‑term follow‑up for male COVID‑19 patients with fertility needs is of great significance. © 2022, Editorial Board of Medical Journal of Wuhan University. All right reserved.
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Full text: Available Collection: Databases of international organizations Database: Scopus Type of study: Experimental Studies Language: Chinese Journal: Medical Journal of Wuhan University Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Scopus Type of study: Experimental Studies Language: Chinese Journal: Medical Journal of Wuhan University Year: 2022 Document Type: Article