Analysis of the examination indicators of 25 cases of SARS‑CoV‑2 nucleic acid re‑positive patients

ABSTRACT

Objective: To analyze the clinical characteristics and laboratory indices of 25 SARS‑CoV‑2 nucleic acid re⁃positive patients who reached the discharge standard after quarantined at hotels after 2 or 4 weeks. Methods: The clinical data of 25 re‑positive COVID⁃19 patients admitted to Dongfeng Hospital of Hubei University of Medicine from January to April 2020 were retrospectively analyzed at different time points (the first diagnosis, hospital discharge, and re⁃test positive after treatment). Results: Lymphocyte counts (LYM) were significantly different among each periods (all P<0.05). Compared with that at the first diagnosis, hsCRP level at re‑positive and discharge time was significantly reduced (both P<0.05), the Ct value of the SARS‑CoV‑2 nucleic acid test and WBC count were significantly increased (all P<0.05). The NEU%, LYM%, and PCT showed no statistical changes among all time points (all P>0.05). Compared with that at hospital discharge, better or none changes in lung CT images were found in the patients when they were found re⁃positives in nucleic acid test. Conclusion: In SARS‑CoV‑2 nucleic acid re‑positive patients, progressive increases of LYM and WBC counts, and progressive decrease of hs‑CRP were found. The clinical symptoms and laboratory examination indicators were better than before, we speculated that the re⁃occurrence of SARS‑CoV‑2 infection may have no pathogenic effect on patients, although its infectivity needs to be further investigated. Therefore, the disease control department need to continue to strengthen the follow‑up and prevention management of COVID‑19 discharged patients. © 2022, Editorial Board of Medical Journal of Wuhan University. All right reserved.