Prevalence and clinical outcomes of vitamin D deficiency in COVID-19 hospitalized patients: a retrospective single-center analysis
Tohoku Journal of Experimental Medicine
; 255(2):127-134, 2021.
Article
in English
| CAB Abstracts | ID: covidwho-1601661
ABSTRACT
Vitamin D attenuates inflammatory responses to viral respiratory infections. Hence, vitamin D deficiency may be a highly significant prognostic factor for severity and mortality in COVID-19 patients. To evaluate the complications and mortality in different vitamin D status groups in COVID-19 hospitalized patients, we conducted this retrospective study on 646 laboratory-confirmed COVID-19 patients who were hospitalized in Shahid Modarres Hospital, Tehran, Iran from 16th March 2020 until 25th February 2021. Overall, patients with vitamin D deficiency, insufficiency and sufficiency were 16.9%, 43.6% and 39.5%, respectively. The presence of comorbidity, length of hospitalization, ICU admission, and invasive mechanical ventilation requirement and overall complications were significantly more in patients with vitamin D deficiency (p-value < 0.001). 46.8% (51/109) of vitamin D deficient patients died due to the disease, whilst the mortality rate among insufficient and sufficient vitamin D groups was 29.4% (83/282) and 5.5% (14/255), respectively. In univariate analysis, age > 60 years (odds ratio (OR) = 6.1), presence of comorbidity (OR = 10.7), insufficient vitamin D status (OR = 7.2), and deficient vitamin D status (OR = 15.1) were associated with increase in COVID-19 mortality (p-value < 0.001). Finally, the multivariate analysis adjusted for age, sex, and comorbidities indicated vitamin D deficiency as an independent risk factor for mortality (OR = 3.3, p-value = 0.002). Vitamin D deficiency is a strong risk factor for mortality and severity of SARS-CoV-2 infection. Vitamin D supplementation may be able to prevent or improve the prognosis of COVID-19 during this pandemic.
Prion, Viral, Bacterial, and, Fungal, Pathogens, of, Humans, [VV210]; Non-communicable, Human, Diseases, and, Injuries, [VV600]; Nutrition, related, Disorders, and, Therapeutic, Nutrition, [VV130]; artificial, respiration; complications; coronavirus, disease, 2019; disease, prevalence; epidemiology; hospital, admission; human, diseases; inflammation; intensive, care, units; mortality; nutritional, state; prognosis; respiratory, diseases; respiratory, system; retrospective, studies; risk; risk, assessment; risk, factors; risk, reduction; viral, diseases; vitamin, D; vitamin, D, deficiency; vitamin, deficiencies; vitamin, supplements; man; Severe, acute, respiratory, syndrome, coronavirus, 2; Iran; high, Human, Development, Index, countries; lower-middle, income, countries; Middle, East; West, Asia; Asia; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe, acute, respiratory, syndrome-related, coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense, ssRNA, Viruses; ssRNA, Viruses; RNA, Viruses; viruses; death, rate; nutritional, status; lung, diseases; SARS-CoV-2; viral, infections
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Collection:
Databases of international organizations
Database:
CAB Abstracts
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Tohoku Journal of Experimental Medicine
Year:
2021
Document Type:
Article
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