A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents.
Mol Divers
; 26(5): 2967-2980, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-1602841
ABSTRACT
Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen and or oxygen as heteroatoms in their structures. Several research groups have synthesized diversely substituted 1,2,4-oxadiazoles as anti-infective agents having anti-bacterial, anti-viral, anti-leishmanial, etc. activities. For the first time, the present review article will provide the coverage of synthetic account of 1,2,4-oxadiazoles as anti-infective agents along with their potential for SAR, activity potential, promising target for mode of action. The efforts have been made to provide the chemical intuitions to the reader to design new chemical entity with potential of anti-infective activity. This review will mark the impact as the valuable, comprehensive and pioneered work along with the library of synthetic strategies for the organic and medicinal chemists for further refinement of 1,2,4-oxadiazole as anti-infective agents.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oxadiazoles
/
Anti-Infective Agents
Type of study:
Experimental Studies
/
Randomized controlled trials
Language:
English
Journal:
Mol Divers
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
S11030-021-10375-4
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