Clinical heterogeneity in patients with myoclonus associated to COVID-19.
Neurol Sci
; 43(3): 1587-1592, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1603464
ABSTRACT
OBJECTIVE:
This study aims to report the clinical heterogeneity of myoclonus in 6 patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).METHODS:
Patient data were obtained from medical records from the University Hospital Dr. Josep Trueta, Girona, Spain.RESULTS:
Six patients (5 men and 1 woman, aged 60-76 years) presented with different myoclonus phenotypes. All of them had a medical history of hypertension and overweight. The latency of myoclonus appearance ranged from 1 to 129 days. The phenotype most observed was generalized myoclonus. Special phenotypes such as painful legs and moving toes syndrome with jerking feet, Lazarus sign-like, action myoclonus/ataxia syndrome, and segmental myoclonus secondary to myelitis have been described too. Levetiracetam and clonazepam were medications most used successfully. Two patients died for complications not related to myoclonus.CONCLUSIONS:
Our 6 cases highlight the heterogeneity of the clinical spectrum of myoclonus associated to COVID-19 (MYaCO). MYaCO pathogenesis is suspected to be due to an immune-mediated para- or post-infectious phenomenon; nevertheless, further research is needed to elucidate this hypothesis.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cerebellar Ataxia
/
COVID-19
/
Myoclonus
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Neurol Sci
Journal subject:
Neurology
Year:
2022
Document Type:
Article
Affiliation country:
S10072-021-05802-1
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