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Clinical Effectiveness of REGN-COV2 in Patients with COVID-19 in Japan: A Retrospective Cohort Study with a Bayesian Inference.
Amano, Norihiko; Iwata, Kentaro; Iwata, Sachiyo.
  • Amano N; Division of Rheumatology, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Hyogo, Japan.
  • Iwata K; Division of Infectious Diseases, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Hyogo, Japan.
  • Iwata S; Division of Infectious Diseases Therapeutics, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. kentaroiwata1969@gmail.com.
Infect Chemother ; 53(4): 767-775, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1603475
ABSTRACT

BACKGROUND:

Neutralizing antibody cocktail therapy, REGN-COV2, is promising in preventing a severe form of coronavirus disease 2019 (COVID-19), but its effectiveness in Japan has not been fully investigated. MATERIALS AND

METHODS:

To evaluate the effectiveness of REGN-COV2, clinical data of 20 patients with COVID-19 who received REGN-COV2 was compared with the control by matching age and sex. The primary outcome was the time from the onset to defervescence, the duration of hospitalization, and oxygen requirement. A sensitivity analysis using Bayesian analysis was also conducted.

RESULTS:

The time to defervescence was significantly shorter in the treatment group (5.25 vs. 7.95 days, P = 0.02), and so was the duration of hospitalization (7.115 vs. 11.45, P = 0.0009). However, the oxygen therapy requirement did not differ between the two groups (15% vs. 35%, P = 0.27). For Bayesian analysis, the median posterior probability of the time to defervescence since the symptom onset on the REGN-COV2 group was 5.28 days [95% credible interval (CrI) 4.28 - 6.31 days], compared with the control of 7.99 days (95% CrI 6.81 - 9.24 days). The posterior probability of the duration of the hospitalization on the REGN-COV2 group was 7.17 days (95% CrI 5.99 - 8.24 days), compared with the control of 11.54 days (95% CrI 10.28 - 13.14 days). The posterior probability of the oxygen requirement on the REGN-COV2 group was 18% (95% CrI 3 - 33%), compared with the control of 36% (95% CrI 16 - 54%).

CONCLUSION:

REGN-COV2 may be effective in early defervescence and shorter hospitalization. Its effectiveness for preventing a severe form of infection needs to be evaluated by further studies.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Infect Chemother Year: 2021 Document Type: Article Affiliation country: Ic.2021.0125

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Infect Chemother Year: 2021 Document Type: Article Affiliation country: Ic.2021.0125