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Impact of COVID-19 on in-hospital cardiac arrest outcomes: An updated meta-analysis.
Bielski, Karol; Makowska, Katarzyna; Makowski, Adam; Kopiec, Tomasz; Gasecka, Aleksandra; Malecka, Mariola; Pruc, Michal; Rafique, Zubaid; Peacock, Frank W; Denegri, Andrea; Szarpak, Lukasz.
  • Bielski K; Research Unit, Polonia University, Czestochowa, Poland.
  • Makowska K; Provincial Emergency Medical Service Dispatcher, Warsaw, Poland.
  • Makowski A; First Chair and Department of Cardiology, Medical University of Warsaw, Poland.
  • Kopiec T; First Chair and Department of Cardiology, Medical University of Warsaw, Poland.
  • Gasecka A; First Chair and Department of Cardiology, Medical University of Warsaw, Poland.
  • Malecka M; First Chair and Department of Cardiology, Medical University of Warsaw, Poland.
  • Pruc M; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland.
  • Rafique Z; Research Unit, Polish Society of Disaster Medicine, Warsaw, Poland.
  • Peacock FW; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, United States.
  • Denegri A; Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, United States.
  • Szarpak L; Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy.
Cardiol J ; 28(6): 816-824, 2021.
Article in English | MEDLINE | ID: covidwho-1603899
ABSTRACT

BACKGROUND:

The main purposes of this meta-analysis are to update the information about the impact of coronavirus disease 2019 (COVID-19) pandemic on outcomes of in-hospital cardiac arrest (IHCA) and to investigate the impact of being infected by by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) on IHCA outcomes.

METHODS:

The current meta-analysis is an update and follows the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

RESULTS:

In analyses, pre- and intra-COVID-19 periods were observed for shockable rhythms in 17.6% vs. 16.2% (odds ratio [OR] 1.11; 95% confidence interval [CI] 0.71-1.72; p = 0.65), return of spontaneous circulation (ROSC) in 47.4% vs. 44.0% (OR 1.36; 95% CI 0.90-2.07; p = 0.15), 30-day mortality in 59.8% vs. 60.9% (OR 0.95; 95% CI 0.75-1.22; p = 0.69) and overall mortality 75.8% vs. 74.7% (OR 0.80; 95% CI 0.49-1.28; p = 0.35), respectively. In analyses, SARS-CoV-2 positive and negative patients were observed for shockable rhythms in 9.6% vs. 19.8% (OR 0.51; 95% CI 0.35-0.73; p < 0.001), ROSC in 33.9% vs. 52.1% (OR 0.47; 95% CI 0.30-0.73; p < 0.001), 30-day mortality in 77.2% vs. 59.7% (OR 2.08; 95% CI 1.28-3.38; p = 0.003) and overall mortality in 94.9% vs. 76.7% (OR 3.20; 95% CI 0.98-10.49; p = 0.05), respectively.

CONCLUSIONS:

Despite ROSC, 30-day and overall mortality rate were not statistically different in pre- vs. intra-COVID-19 periods, a lower incidence of ROSC and higher 20-day mortality rate were observed in SARS-CoV-2 (+) compared to SARS-CoV-2 (-) patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiopulmonary Resuscitation / COVID-19 / Heart Arrest Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Cardiol J Year: 2021 Document Type: Article Affiliation country: CJ.a2021.0168

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiopulmonary Resuscitation / COVID-19 / Heart Arrest Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Cardiol J Year: 2021 Document Type: Article Affiliation country: CJ.a2021.0168