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COVID-19 pandemic and mental distress in multiple sclerosis: Implications for clinical management.
Costabile, Teresa; Carotenuto, Antonio; Lavorgna, Luigi; Borriello, Giovanna; Moiola, Lucia; Inglese, Matilde; Petruzzo, Martina; Trojsi, Francesca; Ianniello, Antonio; Nozzolillo, Agostino; Cellerino, Maria; Boffa, Giacomo; Rosa, Laura; Servillo, Giuseppe; Moccia, Marcello; Bonavita, Simona; Filippi, Massimo; Lanzillo, Roberta; Brescia Morra, Vincenzo; Petracca, Maria.
  • Costabile T; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
  • Carotenuto A; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
  • Lavorgna L; Second Division of Neurology, Multiple Sclerosis Center, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Borriello G; MS Center, S. Andrea Hospital, Sapienza University, Rome, Italy.
  • Moiola L; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Inglese M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
  • Petruzzo M; Ospedale Policlinico San Martino IRCCS, Genoa, Italy.
  • Trojsi F; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
  • Ianniello A; Second Division of Neurology, Multiple Sclerosis Center, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Nozzolillo A; MS Center, S. Andrea Hospital, Sapienza University, Rome, Italy.
  • Cellerino M; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Boffa G; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
  • Rosa L; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
  • Servillo G; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
  • Moccia M; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
  • Bonavita S; Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy.
  • Filippi M; Second Division of Neurology, Multiple Sclerosis Center, University of Campania Luigi Vanvitelli, Naples, Italy.
  • Lanzillo R; Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Brescia Morra V; Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Petracca M; Neurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Eur J Neurol ; 28(10): 3375-3383, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1604393
Semantic information from SemMedBD (by NLM)
1. Mental distress COEXISTS_WITH Multiple Sclerosis
Subject
Mental distress
Predicate
COEXISTS_WITH
Object
Multiple Sclerosis
2. COVID-19 COEXISTS_WITH Multiple Sclerosis
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Multiple Sclerosis
3. Multiple Sclerosis PROCESS_OF Persons
Subject
Multiple Sclerosis
Predicate
PROCESS_OF
Object
Persons
4. Mental distress PROCESS_OF Persons
Subject
Mental distress
Predicate
PROCESS_OF
Object
Persons
5. Motor disability PREDISPOSES Disability
Subject
Motor disability
Predicate
PREDISPOSES
Object
Disability
6. IMPACT gene AFFECTS Depressive disorder
Subject
IMPACT gene
Predicate
AFFECTS
Object
Depressive disorder
7. Mental distress COEXISTS_WITH Multiple Sclerosis
Subject
Mental distress
Predicate
COEXISTS_WITH
Object
Multiple Sclerosis
8. COVID-19 COEXISTS_WITH Multiple Sclerosis
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
Multiple Sclerosis
9. Multiple Sclerosis PROCESS_OF Persons
Subject
Multiple Sclerosis
Predicate
PROCESS_OF
Object
Persons
10. Mental distress PROCESS_OF Persons
Subject
Mental distress
Predicate
PROCESS_OF
Object
Persons
11. Motor disability PREDISPOSES Disability
Subject
Motor disability
Predicate
PREDISPOSES
Object
Disability
12. IMPACT gene AFFECTS Depressive disorder
Subject
IMPACT gene
Predicate
AFFECTS
Object
Depressive disorder
ABSTRACT
BACKGROUND AND

PURPOSE:

In multiple sclerosis (MS), disease-related factors and dysfunctional coping might favor the development of mental distress induced by COVID-19 containment measures. Aim of this study was exploring the relationship between disability, coping strategies, daily life reorganization and neuropsychiatric symptoms in an Italian MS population during the COVID-19 lockdown, in order to identify potentially modifiable factors that could inform clinical management of mental distress in people with MS.

METHODS:

We explored the relationship between mental distress, disability and coping strategies in the Italian MS population under lockdown. Structural equation modeling was applied to information collected via web survey to identify modifiable factors that could account for mental distress.

RESULTS:

A total of 845 participants (497 with MS and 348 controls) were included in the study. The MS group had higher scores than the control group for depression (p = 0.005), but not for anxiety, emotional dyscontrol or sleep disturbances. The structural equation modeling explained 74% of the variance observed in depression score. Within the model, three latent factors were characterized from measured variables motor disability and cognitive dysfunction contributed to disability (ß = 0.509 and ß = 0.836; p < 0.001); positive attitude and exercise contributed to active attitude (ß = 0.386 and ß = 0.297; p < 0.001); and avoidance, social support and watching television contributed to passive attitude (ß = 0.301, ß = 0.243 and ß = 0.212; p < 0.001). With regard to the relationship between latent factors and their influence on depression, disability contributed to passive attitude (ß = 0.855; p < 0.001), while both passive and active attitude significantly influenced depression (ß = 0.729 and ß = -0.456; p < 0.001).

CONCLUSION:

As a practical implication of our model, favoring exercise would enhance active attitude and its positive impact on mental well-being while, at the same time, reducing the negative impact of disability on depression, representing a valuable tool in facing COVID-19-related mental distress.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Disabled Persons / Motor Disorders / COVID-19 / Multiple Sclerosis Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Ene.14580

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Disabled Persons / Motor Disorders / COVID-19 / Multiple Sclerosis Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Ene.14580