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Clinical features, demography, and predictors of outcomes of SARS-CoV-2 infection at a tertiary care hospital in India: A cohort study.
Elavarasi, Arunmozhimaran; Raju Sagiraju, Hari Krishna; Garg, Rohit Kumar; Ratre, Brajesh; Sirohiya, Prashant; Gupta, Nishkarsh; Garg, Rakesh; Pandit, Anuja; Vig, Saurabh; Singh, Ram; Kumar, Balbir; Meena, Ved Prakash; Wig, Naveet; Mittal, Saurabh; Pahuja, Sourabh; Madan, Karan; Guleria, Randeep; Mohan, Anant; Dwivedi, Tanima; Gupta, Ritu; Vidyarthi, Ashima Jain; Chaudhry, Rama; Das, Arghya; Wundavalli, LaxmiTej; Singh, Angel Rajan; Singh, Sheetal; Kumar, Sunil; Pandey, Manisha; Mishra, Abhinav; Matharoo, Karanvir Singh; Bhatnagar, Sushma.
  • Elavarasi A; Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
  • Raju Sagiraju HK; Department of Preventive Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Garg RK; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Ratre B; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Sirohiya P; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Gupta N; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Garg R; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Pandit A; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Vig S; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Singh R; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Kumar B; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Meena VP; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Wig N; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Mittal S; Department of Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Pahuja S; Department of Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Madan K; Department of Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Guleria R; Department of Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Mohan A; Department of Pulmonary Medicine, Critical Care and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Dwivedi T; Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Gupta R; Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Vidyarthi AJ; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • Chaudhry R; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • Das A; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
  • Wundavalli L; Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India.
  • Singh AR; Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India.
  • Singh S; Department of Hospital Administration, All India Institute of Medical Sciences, New Delhi, India.
  • Kumar S; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.
  • Pandey M; Department of Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Mishra A; Department of Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Matharoo KS; Department of Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Bhatnagar S; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
Lung India ; 39(1): 16-26, 2022.
Article in English | MEDLINE | ID: covidwho-1604705
Preprint
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ABSTRACT

BACKGROUND:

The "second wave" of the COVID-19 pandemic hit India from early April 2021 to June 2021. We describe the clinical features, treatment trends, and baseline laboratory parameters of a cohort of patients with SARS-CoV-2 infection and their association with the outcome.

METHODS:

This was a retrospective cohort study. Multivariate logistic regression models were fitted to identify clinical and biochemical predictors of developing hypoxia, deterioration during the hospital stay, and death.

RESULTS:

A total of 2080 patients were included. The case fatality rate was 19.5%. Among the survivors, the median duration of hospital stay was 8 (5-11) days. Out of 853 (42.3%%) of patients who had COVID-19 acute respiratory distress syndrome at presentation, 340 (39.9%) died. Patients aged >45 years had higher odds of death as compared to the 18-44 years age group. Vaccination reduced the odds of death by 40% (odds ratio [OR] [95% confidence interval [CI]] 0.6 [0.4-0.9], P = 0.032). Patients with hyper inflammation at baseline as suggested by leukocytosis (OR [95% CI] 2.1 [1.5-3.1], P < 0.001), raised d-dimer >500 mg/dL (OR [95% CI] 3.2 [2.2-4.7], P < 0.001), and raised C-reactive peptide >0.5 mg/L (OR [95% CI] 3.7 [2.2-13], P = 0.037) had higher odds of death. Patients who were admitted in the 2nd week had lower odds and those admitted in the 3rd week had higher odds of death.

CONCLUSION:

This study shows that vaccination status and early admission during the inflammatory phase can change the course of illness of these patients. Improving vaccination rates and early admission of patients with moderate and severe COVID-19 can improve the outcomes.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Prognostic study / Risk factors Topics: Vaccines Language: English Journal: Lung India Year: 2022 Document Type: Article Affiliation country: Lungindia.lungindia_493_21

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Prognostic study / Risk factors Topics: Vaccines Language: English Journal: Lung India Year: 2022 Document Type: Article Affiliation country: Lungindia.lungindia_493_21