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COVID-19: an In Silico Analysis on Potential Therapeutic Uses of Trikadu as Immune System Boosters.
Khasamwala, Rukaiya Hasani; Ranjani, S; Nivetha, S Sai; Hemalatha, S.
  • Khasamwala RH; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048.
  • Ranjani S; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048.
  • Nivetha SS; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048.
  • Hemalatha S; School of Life Sciences, B. S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India, 600048. hemalatha.sls@bsauniv.ac.in.
Appl Biochem Biotechnol ; 194(1): 291-301, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1748423
ABSTRACT
Corona virus pandemic outbreak also known as COVID-19 has created an imbalance in this world. Scientists have adopted the use of natural or alternative medicines which are consumed mostly as dietary supplements to boost the immune system as herbal remedies. India is famous for traditional medicinal formulations which includes 'Trikadu'-a combination of three acrids, namely Zingiber officinale, Piper nigrum and Piper longum which have antioxidant properties that boost our immune system hence acting as a strong preventive measure. In this study, AutoDock 4.0 was used to study interaction between the phytocompounds of Trikadu with RNA-dependent polymerase protein and enveloped protein of the SARS-CoV-2 virus. Analysis of the results showed that coumarin, coumaperine and bisdemethoxycurcumin showed strong bonding interactions with both the proteins. We can conclude that Trikadu has the potential molecules; hence, it can be incorporated in the diet to boost the immune system as a preventive measure against the virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plant Preparations / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment / Phytotherapy Topics: Traditional medicine / Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Appl Biochem Biotechnol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Plant Preparations / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment / Phytotherapy Topics: Traditional medicine / Vaccines Limits: Humans Country/Region as subject: Asia Language: English Journal: Appl Biochem Biotechnol Year: 2022 Document Type: Article