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Kinetic Characteristics of Neutralizing Antibody Responses Vary among Patients with COVID-19.
Li, Ling Hua; Tu, Hong Wei; Liang, Dan; Wen, Chun Yan; Li, An An; Lin, Wei Yin; Hu, Ke Qi; Hong, Wen Shan; Li, Yue Ping; Su, Juan; Zhao, San Tao; Li, Wei; Yuan, Run Yu; Zhou, Ping Ping; Hu, Feng Yu; Tang, Xiao Ping; Ke, Chang Wen; Ke, Bi Xia; Cai, Wei Ping.
  • Li LH; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Tu HW; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Liang D; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Wen CY; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Li AA; School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
  • Lin WY; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Hu KQ; School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
  • Hong WS; Shantou University Medical College, Shantou 515063, Guangdong, China.
  • Li YP; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Su J; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Zhao ST; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Li W; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Yuan RY; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Zhou PP; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Hu FY; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Tang XP; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
  • Ke CW; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Ke BX; Guangdong Provincial Center for Diseases Control and Prevention, Guangzhou 511430, Guangdong, China.
  • Cai WP; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, Guangdong, China.
Biomed Environ Sci ; 34(12): 976-983, 2021 Dec 20.
Article in English | MEDLINE | ID: covidwho-1606117
ABSTRACT

OBJECTIVE:

The coronavirus disease 2019 (COVID-19) pandemic continues to present a major challenge to public health. Vaccine development requires an understanding of the kinetics of neutralizing antibody (NAb) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS:

In total, 605 serum samples from 125 COVID-19 patients (from January 1 to March 14, 2020) varying in age, sex, severity of symptoms, and presence of underlying diseases were collected, and antibody titers were measured using a micro-neutralization assay with wild-type SARS-CoV-2.

RESULTS:

NAbs were detectable approximately 10 days post-onset (dpo) of symptoms and peaked at approximately 20 dpo. The NAb levels were slightly higher in young males and severe cases, while no significant difference was observed for the other classifications. In follow-up cases, the NAb titer had increased or stabilized in 18 cases, whereas it had decreased in 26 cases, and in one case NAbs were undetectable at the end of our observation. Although a decreasing trend in NAb titer was observed in many cases, the NAb level was generally still protective.

CONCLUSION:

We demonstrated that NAb levels vary among all categories of COVID-19 patients. Long-term studies are needed to determine the longevity and protective efficiency of NAbs induced by SARS-CoV-2.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Biomed Environ Sci Journal subject: Environmental Health Year: 2021 Document Type: Article Affiliation country: Bes2021.133

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / COVID-19 / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Biomed Environ Sci Journal subject: Environmental Health Year: 2021 Document Type: Article Affiliation country: Bes2021.133