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Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years.
Li, Jia; Zheng, Yali; Zhao, Lili; Yue, Zhihong; Pan, Feng; Chen, Yuehong; Yu, Bing; Chen, Yanwen; Zhao, Guangyu; Zhou, Yusen; Gao, Zhancheng.
  • Li J; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China.
  • Zheng Y; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China.
  • Zhao L; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China.
  • Yue Z; Department of Clinical Laboratory, Peking University People's Hospital, Beijing, 100044, China.
  • Pan F; Department of Radiology, Peking University People's Hospital, Beijing, 100044, China.
  • Chen Y; Institute of Microbial Epidemiology, Academy of Military Medical Sciences, Beijing, 100039, China.
  • Yu B; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China.
  • Chen Y; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China.
  • Zhao G; Institute of Microbial Epidemiology, Academy of Military Medical Sciences, Beijing, 100039, China.
  • Zhou Y; Institute of Microbial Epidemiology, Academy of Military Medical Sciences, Beijing, 100039, China.
  • Gao Z; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, 100044, China. zcgao@bjmu.edu.cn.
BMC Infect Dis ; 21(1): 1183, 2021 Nov 24.
Article in English | MEDLINE | ID: covidwho-1606168
ABSTRACT

BACKGROUND:

We investigate the long-term effects of SARS-CoV on patients' lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003-2004.

METHODS:

We enrolled 58 healthcare workers from Peking University People's Hospital who were infected with SARS-CoV in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera.

RESULTS:

After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL (CO), RV, and FEF25-75, respectively. 17 (30.4%) subjects had an mMRC score ≥ 2. Fourteen (25.5%) cases had residual CT abnormalities. T regulatory cells were a bit higher in the SARS survivors. IgG antibodies against SARS S-RBD protein and N protein were detected in 11 (18.97%) and 12 (20.69%) subjects, respectively. Subgroup analysis revealed that small airway dysfunction and CT abnormalities were more common in the severe group than in the non-severe group (57.1% vs 22.6%, 54.5% vs 6.1%, respectively, p < 0.05).

CONCLUSIONS:

SARS-CoV could cause permanent damage to the lung, which requires early pulmonary rehabilitation. The long-lived immune memory response against coronavirus requires further studies to assess the potential benefit. Trial registration ClinicalTrials.gov, NCT03443102. Registered prospectively on 25 January 2018.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Antibodies, Viral Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06881-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Antibodies, Viral Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06881-3