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Neurological outcome and quality of life 3 months after COVID-19: A prospective observational cohort study.
Rass, Verena; Beer, Ronny; Schiefecker, Alois Josef; Kofler, Mario; Lindner, Anna; Mahlknecht, Philipp; Heim, Beatrice; Limmert, Victoria; Sahanic, Sabina; Pizzini, Alex; Sonnweber, Thomas; Tancevski, Ivan; Scherfler, Christoph; Zamarian, Laura; Bellmann-Weiler, Rosa; Weiss, Günter; Djamshidian, Atbin; Kiechl, Stefan; Seppi, Klaus; Loeffler-Ragg, Judith; Pfausler, Bettina; Helbok, Raimund.
  • Rass V; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Beer R; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Schiefecker AJ; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kofler M; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Lindner A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Mahlknecht P; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Heim B; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Limmert V; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Sahanic S; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Pizzini A; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Sonnweber T; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Tancevski I; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Scherfler C; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Zamarian L; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Bellmann-Weiler R; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Weiss G; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Djamshidian A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Kiechl S; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Seppi K; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Loeffler-Ragg J; Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria.
  • Pfausler B; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • Helbok R; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Eur J Neurol ; 28(10): 3348-3359, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1607398
Semantic information from SemMedBD (by NLM)
1. ambulatory care services TREATS COVID-19
Subject
ambulatory care services
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TREATS
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COVID-19
2. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
3. ambulatory care services TREATS Patients
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ambulatory care services
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Patients
4. 29+ COEXISTS_WITH Acute Disease
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COEXISTS_WITH
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Acute Disease
5. ambulatory care services TREATS COVID-19
Subject
ambulatory care services
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COVID-19
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Subject
COVID-19
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PROCESS_OF
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Patients
7. ambulatory care services TREATS Patients
Subject
ambulatory care services
Predicate
TREATS
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Patients
8. 29+ COEXISTS_WITH Acute Disease
Subject
29+
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COEXISTS_WITH
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Acute Disease
ABSTRACT
BACKGROUND AND

PURPOSE:

To assess neurological manifestations and health-related quality of life (QoL) 3 months after COVID-19.

METHODS:

In this prospective, multicenter, observational cohort study we systematically evaluated neurological signs and diseases by detailed neurological examination and a predefined test battery assessing smelling disorders (16-item Sniffin Sticks test), cognitive deficits (Montreal Cognitive Assessment), QoL (36-item Short Form), and mental health (Hospital Anxiety and Depression Scale, Posttraumatic Stress Disorder Checklist-5) 3 months after disease onset.

RESULTS:

Of 135 consecutive COVID-19 patients, 31 (23%) required intensive care unit (ICU) care (severe), 72 (53%) were admitted to the regular ward (moderate), and 32 (24%) underwent outpatient care (mild) during acute disease. At the 3-month follow-up, 20 patients (15%) presented with one or more neurological syndromes that were not evident before COVID-19. These included polyneuro/myopathy (n = 17, 13%) with one patient presenting with Guillain-Barré syndrome, mild encephalopathy (n = 2, 2%), parkinsonism (n = 1, 1%), orthostatic hypotension (n = 1, 1%), and ischemic stroke (n = 1, 1%). Objective testing revealed hyposmia/anosmia in 57/127 (45%) patients at the 3-month follow-up. Self-reported hyposmia/anosmia was lower (17%) at 3 months, however, improved when compared to the acute disease phase (44%; p < 0.001). At follow-up, cognitive deficits were apparent in 23%, and QoL was impaired in 31%. Assessment of mental health revealed symptoms of depression, anxiety, and posttraumatic stress disorders in 11%, 25%, and 11%, respectively.

CONCLUSIONS:

Despite recovery from the acute infection, neurological symptoms were prevalent at the 3-month follow-up. Above all, smelling disorders were persistent in a large proportion of patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Controlled clinical trial / Etiology study / Incidence study / Observational study / Risk factors Limits: Humans Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Ene.14803

Full text: Available Collection: International databases Database: MEDLINE Main subject: Stroke / COVID-19 Type of study: Controlled clinical trial / Etiology study / Incidence study / Observational study / Risk factors Limits: Humans Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: Ene.14803