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Assessment of SARS-CoV-2 Immunity in Convalescent Children and Adolescents.
Tsang, Hing Wai; Chua, Gilbert T; To, Kelvin K W; Wong, Joshua S C; Tu, Wenwei; Kwok, Janette S Y; Wong, Wilfred H S; Wang, Xiwei; Zhang, Yanmei; Rosa Duque, Jaime S; Chan, Godfrey C F; Chu, Wai Kit; Pang, C P; Tam, Paul K H; Lau, Yu Lung; Wong, Ian C K; Leung, W H; Yuen, Kwok-Yung; Kwan, Mike Y W; Ip, Patrick.
  • Tsang HW; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Chua GT; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • To KKW; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Wong JSC; Department of Paediatrics and Adolescent Medicine, Prince Margaret Hospital, Hospital Authority, Hong Kong, Hong Kong SAR, China.
  • Tu W; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Kwok JSY; Department of Pathology, Queen Mary Hospital, Hospital Authority, Hong Kong, Hong Kong SAR, China.
  • Wong WHS; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Wang X; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Zhang Y; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Rosa Duque JS; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Chan GCF; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Chu WK; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Pang CP; Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Tam PKH; Department of Surgery and Dr. Li Dak Sam Research Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Lau YL; Faculty of Medicine, Macau University of Science and Technology, Macau, Macau SAR, China.
  • Wong ICK; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Leung WH; Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Yuen KY; Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Kwan MYW; State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
  • Ip P; Department of Paediatrics and Adolescent Medicine, Prince Margaret Hospital, Hospital Authority, Hong Kong, Hong Kong SAR, China.
Front Immunol ; 12: 797919, 2021.
Article in English | MEDLINE | ID: covidwho-1608316
ABSTRACT
Persistence of protective immunity for SARS-CoV-2 is important against reinfection. Knowledge on SARS-CoV-2 immunity in pediatric patients is currently lacking. We opted to assess the SARS-CoV-2 adaptive immunity in recovered children and adolescents, addressing the pediatrics specific immunity towards COVID-19. Two independent assays were performed to investigate humoral and cellular immunological memory in pediatric convalescent COVID-19 patients. Specifically, RBD IgG, CD4+, and CD8+ T cell responses were identified and quantified in recovered children and adolescents. SARS-CoV-2-specific RBD IgG detected in recovered patients had a half-life of 121.6 days and estimated duration of 7.9 months compared with baseline levels in controls. The specific T cell response was shown to be independent of days after diagnosis. Both CD4+ and CD8+ T cells showed robust responses not only to spike (S) peptides (a main target of vaccine platforms) but were also similarly activated when stimulated by membrane (M) and nuclear (N) peptides. Importantly, we found the differences in the adaptive responses were correlated with the age of the recovered patients. The CD4+ T cell response to SARS-CoV-2 S peptide in children aged <12 years correlated with higher SARS-CoV-2 RBD IgG levels, suggesting the importance of a T cell-dependent humoral response in younger children under 12 years. Both cellular and humoral immunity against SARS-CoV-2 infections can be induced in pediatric patients. Our important findings provide fundamental knowledge on the immune memory responses to SARS-CoV-2 in recovered pediatric patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Convalescence / Antibodies, Neutralizing / Adaptive Immunity / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.797919

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Convalescence / Antibodies, Neutralizing / Adaptive Immunity / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.797919