A systematic review of Vaccine Breakthrough Infections by SARS-CoV-2 Delta Variant
International journal of biological sciences
; 18(2):889-900, 2022.
Article
in English
| EuropePMC | ID: covidwho-1610605
ABSTRACT
Vaccines are proving to be highly effective in controlling hospitalization and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as shown by clinical trials and real-world evidence. However, a deadly second wave of coronavirus disease 2019 (COVID-19), infected by SARS-CoV-2 variants, especially the Delta (B.1.617.2) variant, with an increased number of post-vaccination breakthrough infections were reported in the world recently. Actually, Delta variant not only resulted in a severe surge of vaccine breakthrough infections which was accompanied with high viral load and transmissibility, but also challenged the development of effective vaccines. Therefore, the biological characteristics and epidemiological profile of Delta variant, the current status of Delta variant vaccine breakthrough infections and the mechanism of vaccine breakthrough infections were discussed in this article. In addition, the significant role of the Delta variant spike (S) protein in the mechanism of immune escape of SARS-CoV-2 was highlighted in this article. In particular, we further discussed key points on the future SARS-CoV-2 vaccine research and development, hoping to make a contribution to the early, accurate and rapid control of the COVID-19 epidemic.
Search on Google
Collection:
Databases of international organizations
Database:
EuropePMC
Type of study:
Reviews
/
Systematic review/Meta Analysis
Topics:
Vaccines
/
Variants
Language:
English
Journal:
International journal of biological sciences
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS