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New C9 -Monoterpenoid Alkaloids Featuring a Rare Skeleton with Anti-Inflammatory and Antiviral Activities from Forsythia suspensa.
Li, Wei; Sun, Li-Tong; Zhao, Lin; Yue, Xi-Dian; Dai, Sheng-Jun.
  • Li W; School of Pharmaceutical Science, Yantai University, Yantai, 264005, P. R. China.
  • Sun LT; School of Pharmaceutical Science, Yantai University, Yantai, 264005, P. R. China.
  • Zhao L; School of Pharmaceutical Science, Yantai University, Yantai, 264005, P. R. China.
  • Yue XD; College of Life Sciences, Yantai University, Yantai, 264005, P. R. China.
  • Dai SJ; School of Pharmaceutical Science, Yantai University, Yantai, 264005, P. R. China.
Chem Biodivers ; 19(1): e202100668, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1611203
ABSTRACT
Forsyqinlingines C (1) and D (2), two C9 -monoterpenoid alkaloids bearing a rare skeleton, were isolated from the ripe fruits of Forsythia suspensa. Their structures, including absolute configurations, were fully elucidated by extensive spectroscopic data and ECD experiments. The plausible biogenetic pathway for compounds 1 and 2 was also proposed. In vitro, two C9 -monoterpenoid alkaloids showed anti-inflammatory activity performed by the inhibitory effect on the release of ß-glucuronidase in rat polymorphonuclear leukocytes (PMNs), as well as antiviral activity against influenza A (H1N1) virus and respiratory syncytial virus (RSV).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Forsythia / Monoterpenes / Alkaloids / Anti-Inflammatory Agents Limits: Animals Language: English Journal: Chem Biodivers Journal subject: Biochemistry / Chemistry Year: 2022 Document Type: Article Affiliation country: Cbdv.202100668

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Forsythia / Monoterpenes / Alkaloids / Anti-Inflammatory Agents Limits: Animals Language: English Journal: Chem Biodivers Journal subject: Biochemistry / Chemistry Year: 2022 Document Type: Article Affiliation country: Cbdv.202100668