One-step and sequential SARSCOV-2 polymerase chain reaction tests would not work every time.
J Clin Lab Anal
; 36(2): e24226, 2022 Feb.
Article
in English
| MEDLINE | ID: covidwho-1611241
ABSTRACT
INTRODUCTION:
RT-PCR is widely used as a diagnostic test for the detection of SARS-CoV-2. In this study, we aim to describe the clinical utility of serial PCR testing in the final detection of COVID-19.METHOD:
We collected multiple nasopharyngeal swab samples from patients who had negative RT-PCR test on the first day after hospitalization. RT-PCR tests were performed on the second day for all patients with initial negative result. For the patients with secondary negative results on day 2, tertiary RT-PCR tests were performed on day 3 after hospitalization.RESULT:
Among 68 patients with initial negative test results, at the end of follow-up, the mortality number was 20 (29.4%). About 33.8% of patients had subsequent positive PCR test results for the second time and 17.4% of the patients who performed third PCR test had positive result.CONCLUSION:
Based on this study, serial RT-PCR testing is unlikely to yield additional information.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Molecular Diagnostic Techniques
/
Real-Time Polymerase Chain Reaction
/
SARS-CoV-2
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Clin Lab Anal
Journal subject:
Laboratory Techniques and procedures
Year:
2022
Document Type:
Article
Affiliation country:
Jcla.24226
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