Asthma and PTSD association: relevant models and a role of IL17AA
Psychoneuroendocrinology
; 131, 2021.
Article
in English
| EMBASE | ID: covidwho-1611981
ABSTRACT
Background:
Strong genetic and epidemiological evidence supports an asthma-PTSD association, however, contributory immune mediators/mechanisms are unclear. Here, we examined a direct role of severe asthma associated Th17/ IL-17A in regulating PTSD-relevant behaviors using mouse aeroallergen house dust mite (HDM) models.Methods:
3 strategies were used 1) BALBc-C5a receptor treatment that shifts Th2 mild asthma phenotype to Th17/IL17a expansion;2) IL-17a receptor knockout mice and 3) sufficiency testing with intracerebroventricular (ICV) administration of recombinant IL17a effects on behavior. Fear conditioning and extinction, maze exploration and social behaviors were assessed.Results:
Absence of IL-17 signaling attenuated HDM effects on fear extinction while induction of Th17/IL-17 in the BALBc/anti-C5aR1 treated mice resulted in compromised fear extinction. ICV IL-17a promoted an anxiogenic phenotype and impaired social behaviors. Preliminary evidence suggests a role of cortical mechanisms (under investigation).Conclusion:
Overall, our work highlights severe asthma inflammatory mediator IL17a in regulating PTSD-relevant behaviors. Beyond asthma-PTSD, our findings have relevant implications for other pulmonary (e.g. COVID-19) and autoimmune inflammatory conditions and PTSD risk.
complement, component, C5a, receptor; endogenous, compound; interleukin, 17; animal, experiment; animal, model; conference, abstract; controlled, study; coronavirus, disease, 2019; Dermatophagoides; fear; inflammation; knockout, mouse; male; mouse; nonhuman; phenotype; posttraumatic, stress, disorder; protein, function; severe, asthma; signal, transduction; social, behavior
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Psychoneuroendocrinology
Year:
2021
Document Type:
Article
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