Post-mortem lung tissue: the fossil record of the pathophysiology and immunopathology of severe COVID-19.
Lancet Respir Med
; 10(1): 95-106, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1612130
ABSTRACT
The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tissue architecture, and resident and inflammatory cell phenotypes and composition at the time of death. Contrary to early assumptions that COVID-19 in the lungs is a uniform disease, post-mortem findings have established a high degree of disease heterogeneity. Classic diffuse alveolar damage represents just one phenotype, with disease divisible by early and late progression as well as by pathophysiological process. A distinct lung tissue state occurs with secondary infection; extrapulmonary causes of death might also originate from a pathological process in the lungs linked to microthrombosis. This heterogeneity of COVID-19 lung disease must be recognised in the management of patients and in the development of novel treatment strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Lung
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Lancet Respir Med
Year:
2022
Document Type:
Article
Affiliation country:
S2213-2600(21)00408-2
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