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Inappropriate sinus tachycardia in post-COVID-19 syndrome.
Aranyó, Júlia; Bazan, Victor; Lladós, Gemma; Dominguez, Maria Jesús; Bisbal, Felipe; Massanella, Marta; Sarrias, Axel; Adeliño, Raquel; Riverola, Ariadna; Paredes, Roger; Clotet, Bonaventura; Bayés-Genís, Antoni; Mateu, Lourdes; Villuendas, Roger.
  • Aranyó J; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Bazan V; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Lladós G; Department of Infectious Disease, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
  • Dominguez MJ; Emergency Department, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
  • Bisbal F; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Massanella M; AIDS Research Institute (IrsiCaixa), Badalona, Spain.
  • Sarrias A; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Adeliño R; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Riverola A; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Paredes R; AIDS Research Institute (IrsiCaixa), Badalona, Spain.
  • Clotet B; Department of Infectious Disease, Hospital Universitari Germans Trias I Pujol, Badalona, Spain.
  • Bayés-Genís A; AIDS Research Institute (IrsiCaixa), Badalona, Spain.
  • Mateu L; Cardiology Department, Heart institute, Hospital Universitari Germans Trias I Pujol, Carretera de Canyet s/n, 08916, Badalona, Spain.
  • Villuendas R; Centro de Investigación Biomédica en Red Enfermedades Cardiovascualres (CIBERCV), Madrid, Spain.
Sci Rep ; 12(1): 298, 2022 01 07.
Article in English | MEDLINE | ID: covidwho-1612205
ABSTRACT
Inappropriate sinus tachycardia (IST) is a common observation in patients with post-COVID-19 syndrome (PCS) but has not yet been fully described to date. To investigate the prevalence and the mechanisms underlying IST in a prospective population of PCS patients. Consecutive patients admitted to the PCS Unit between June and December 2020 with a resting sinus rhythm rate ≥ 100 bpm were prospectively enrolled in this study and further examined by an orthostatic test, 2D echocardiography, 24-h ECG monitoring (heart rate variability was a surrogate for cardiac autonomic activity), quality-of-life and exercise capacity testing, and blood sampling. To assess cardiac autonomic function, a 211 comparative sub-analysis was conducted against both fully recovered patients with previous SARS-CoV-2 infection and individuals without prior SARS-CoV-2 infection. Among 200 PCS patients, 40 (20%) fulfilled the diagnostic criteria for IST (average age of 40.1 ± 10 years, 85% women, 83% mild COVID-19). No underlying structural heart disease, pro-inflammatory state, myocyte injury, or hypoxia were identified. IST was accompanied by a decrease in most heart rate variability parameters, especially those related to cardiovagal tone pNN50 (cases 3.2 ± 3 vs. recovered 10.5 ± 8 vs. non-infected 17.3 ± 10; p < 0.001) and HF band (246 ± 179 vs. 463 ± 295 vs. 1048 ± 570, respectively; p < 0.001). IST is prevalent condition among PCS patients. Cardiac autonomic nervous system imbalance with decreased parasympathetic activity may explain this phenomenon.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tachycardia, Sinus / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-021-03831-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tachycardia, Sinus / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Variants Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-021-03831-6