Neural inverse optimal control applied to design therapeutic options for patients with COVID-19
International Joint Conference on Neural Networks (IJCNN)
; 2021.
Article
in English
| Web of Science | ID: covidwho-1612802
ABSTRACT
In this paper we apply an inverse optimal controller (IOC) based on a control Lyapunov function (CLF) to schedule theoretical therapies for the novel coronavirus disease (COVID-19). This controller can represent the viral dynamics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the host. The virus dynamics consider the antiviral effects and immune responses as control inputs. The proposed controller is based on a Recurrent High Order Neural Network (RHONN) used as an identifier trained with Extended Kalman Filter (EKF). Simulations show that applying treatment 2 days post symptoms would not significantly alter the viral load. The proposed controller to stimulate the immune response displays a better effectiveness compared to the effectiveness displayed by the antiviral effects.
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
International Joint Conference on Neural Networks (IJCNN)
Year:
2021
Document Type:
Article
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