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Single cell biology-a Keystone Symposia report.
Cable, Jennifer; Elowitz, Michael B; Domingos, Ana I; Habib, Naomi; Itzkovitz, Shalev; Hamidzada, Homaira; Balzer, Michael S; Yanai, Itai; Liberali, Prisca; Whited, Jessica; Streets, Aaron; Cai, Long; Stergachis, Andrew B; Hong, Clarice Kit Yee; Keren, Leeat; Guilliams, Martin; Alon, Uri; Shalek, Alex K; Hamel, Regan; Pfau, Sarah J; Raj, Arjun; Quake, Stephen R; Zhang, Nancy R; Fan, Jean; Trapnell, Cole; Wang, Bo; Greenwald, Noah F; Vento-Tormo, Roser; Santos, Silvia D M; Spencer, Sabrina L; Garcia, Hernan G; Arekatla, Geethika; Gaiti, Federico; Arbel-Goren, Rinat; Rulands, Steffen; Junker, Jan Philipp; Klein, Allon M; Morris, Samantha A; Murray, John I; Galloway, Kate E; Ratz, Michael; Romeike, Merrit.
  • Cable J; PhD Science Writer, New York, New York.
  • Elowitz MB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
  • Domingos AI; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California.
  • Habib N; Department of Physiology, Anatomy & Genetics, Oxford University, Oxford, United Kingdom.
  • Itzkovitz S; The Howard Hughes Medical Institute, New York, New York.
  • Hamidzada H; Cell Circuits Program, Broad Institute, Cambridge, Massachusetts.
  • Balzer MS; Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Yanai I; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
  • Liberali P; Toronto General Hospital Research Institute, University Health Network; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research and Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
  • Whited J; Renal, Electrolyte, and Hypertension Division, Department of Medicine and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Streets A; Institute for Computational Medicine, NYU Langone Health, New York, New York.
  • Cai L; Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.
  • Stergachis AB; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts.
  • Hong CKY; Department of Bioengineering and Center for Computational Biology, University of California, Berkeley, Berkeley, California.
  • Keren L; Chan Zuckerberg Biohub, San Francisco, California.
  • Guilliams M; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
  • Alon U; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington; and Brotman Baty Institute for Precision Medicine, Seattle, Washington.
  • Shalek AK; Edison Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, Missouri.
  • Hamel R; Department of Genetics, Washington University in St. Louis, St. Louis, Missouri.
  • Pfau SJ; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
  • Raj A; Department of Pathology, School of Medicine, Stanford University, Stanford, California.
  • Quake SR; Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB-UGent Center for Inflammation Research, and Unit of Immunoregulation and Mucosal Immunology, VIB Inflammation Research Center, and Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Zhang NR; Faculty of Sciences, Department of Human Biology, University of Haifa, Haifa, Israel.
  • Fan J; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts.
  • Trapnell C; Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom.
  • Wang B; Department of Neurobiology, Harvard Medical School, Boston, Massachusetts.
  • Greenwald NF; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Vento-Tormo R; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Santos SDM; Chan Zuckerberg Biohub, San Francisco, California.
  • Spencer SL; Department of Bioengineering, Stanford University, Stanford, California.
  • Garcia HG; Department of Applied Physics, Stanford University, Stanford, California.
  • Arekatla G; Graduate Group in Genomics and Computational Biology and Department of Statistics, University of Pennsylvania, Philadelphia, Pennsylvania.
  • Gaiti F; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
  • Arbel-Goren R; Department of Genome Sciences, University of Washington School of Medicine; Brotman Baty Institute for Precision Medicine; and Allen Discovery Center for Cell Lineage Tracing, Seattle, Washington.
  • Rulands S; Department of Bioengineering, Stanford University, Stanford, California.
  • Junker JP; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California.
  • Klein AM; Department of Pathology, School of Medicine, Stanford University, Stanford, California.
  • Morris SA; Wellcome Sanger Institute, Cambridgeshire, United Kingdom.
  • Murray JI; The Francis Crick Institute, London, United Kingdom.
  • Galloway KE; Department of Biochemistry and BioFrontiers Institute, University of Colorado Boulder, Boulder, Colorado.
  • Ratz M; Department of Physics; Biophysics Graduate Group; Department of Molecular and Cell Biology; and Institute for Quantitative Biosciences-QB3, University of California at Berkeley, Berkeley, California.
  • Romeike M; ETH Zurich, Zurich, Switzerland.
Ann N Y Acad Sci ; 1506(1): 74-97, 2021 12.
Article in English | MEDLINE | ID: covidwho-1612914
ABSTRACT
Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state-transcriptional, epigenetic, and other characteristics-can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17-19, 2021, experts in single cell biology met virtually for the Keystone eSymposium "Single Cell Biology" to discuss advances both in single cell applications and technologies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cell Differentiation / Congresses as Topic / Embryonic Development / Cellular Reprogramming / Single-Cell Analysis / Research Report Limits: Animals / Humans Language: English Journal: Ann N Y Acad Sci Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cell Differentiation / Congresses as Topic / Embryonic Development / Cellular Reprogramming / Single-Cell Analysis / Research Report Limits: Animals / Humans Language: English Journal: Ann N Y Acad Sci Year: 2021 Document Type: Article