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Evaluation of Antibody Response to Heterologous Prime-Boost Vaccination with ChAdOx1 nCoV-19 and BNT162b2: An Observational Study.
Firinu, Davide; Perra, Andrea; Campagna, Marcello; Littera, Roberto; Meloni, Federico; Sedda, Francesca; Conti, Maria; Costanzo, Giulia; Erbi, Monica; Usai, Gianmario; Locci, Carlotta; Carta, Mauro Giovanni; Cappai, Riccardo; Orrù, Germano; Del Giacco, Stefano; Coghe, Ferdinando; Chessa, Luchino.
  • Firinu D; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Perra A; Department of Biomedical Sciences, University of Cagliari, 09100 Cagliari, Italy.
  • Campagna M; Associazione per l'Avanzamento della Ricerca per i Trapianti O.d.V., Non Profit Organisation, 09100 Cagliari, Italy.
  • Littera R; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Meloni F; Associazione per l'Avanzamento della Ricerca per i Trapianti O.d.V., Non Profit Organisation, 09100 Cagliari, Italy.
  • Sedda F; Medical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Conti M; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Costanzo G; Department of Biomedical Sciences, University of Cagliari, 09100 Cagliari, Italy.
  • Erbi M; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Usai G; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Locci C; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Carta MG; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Cappai R; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Orrù G; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Del Giacco S; Laboratory Clinical Chemical Analysis and Microbiology, University Hospital of Cagliari, 09042 Cagliari, Italy.
  • Coghe F; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
  • Chessa L; Department of Medical Sciences and Public Health, University of Cagliari, 09100 Cagliari, Italy.
Vaccines (Basel) ; 9(12)2021 Dec 14.
Article in English | MEDLINE | ID: covidwho-1614019
ABSTRACT
In several countries, thrombotic events after vaccination with ChAdOx1 nCoV-19 have led to heterologous messenger RNA (mRNA) boosting. We tested the antibody response to SARS-CoV-2 spike protein four weeks after heterologous priming with the ChAdOx1 (ChAd) vector vaccine followed by boosting with BNT162b2(ChAd/BNT), comparing data of homologous regimen (BNT/BNT, ChAd/ChAd) subjects positive for SARS-CoV-2 after the first dose of BNT162b2 (BNT1dose/CoV2) and convalescent COVID-19.

METHODS:

healthy subjects naïve for SARS-CoV-2 infection were assessed for serum IgG anti-S-RBD response 21 days after priming (T1), 4 (TFULL) and 15 (T15W) weeks after booster dose.

RESULTS:

The median IgG anti-S-RBD levels at TFULL of Chad/BNT group were significantly higher than the BNT/BNT group and ChAd/ChAd. Those of BNT/BNT group were significantly higher than ChAd/ChAd. IgG anti-S-RBD of BNT1dose/CoV2 group were similar to BNT/BNT, ChAd/BNT and ChAd/Chad group. The levels among COVID-19 convalescents were significantly lower than ChAd/BNT, BNT/BNT, ChAd/Chad and BNT1dose/CoV2. The proportion of subjects reaching an anti-S-RBD titer >75 AU/mL, correlated with high neutralizing titer, was 94% in ChAd/BNT and BNT/BNT, 60% in BNT1dose/CoV2, 25% in ChAd/ChAd and 4.2% in convalescents. At T15W the titer of ChAd/BNT was still significantly higher than other vaccine schedules, while the anti-S-RBD decline was reduced for ChAd/ChAd and similar for other combinations.

CONCLUSION:

Our data highlight the magnitude of IgG anti-S-RBD response in ChAd/BNT dosing, supporting the current national guidelines for heterologous boosting.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9121478

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9121478