Your browser doesn't support javascript.
The impact of protein corona on the biological behavior of targeting nanomedicines.
Farshbaf, Masoud; Valizadeh, Hadi; Panahi, Yunes; Fatahi, Yousef; Chen, Meiwan; Zarebkohan, Amir; Gao, Huile.
  • Farshbaf M; Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Valizadeh H; Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Panahi Y; Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Fatahi Y; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Chen M; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Zarebkohan A; Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: zarebkohana@tbzmed.ac.ir.
  • Gao H; Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Sichuan 610041, China. Electronic address: gaohuile@scu.edu.cn.
Int J Pharm ; 614: 121458, 2022 Feb 25.
Article in English | MEDLINE | ID: covidwho-1615600
ABSTRACT
For successful translation of targeting nanomedicines from bench to bedside, it is vital to address their most common drawbacks namely rapid clearance and off-target accumulation. These complications evidently originate from a phenomenon called "protein corona (PC) formation" around the surface of targeting nanoparticles (NPs) which happens once they encounter the bloodstream and interact with plasma proteins with high collision frequency. This phenomenon endows the targeting nanomedicines with a different biological behavior followed by an unexpected fate, which is usually very different from what we commonly observe in vitro. In addition to the inherent physiochemical properties of NPs, the targeting ligands could also remarkably dictate the amount and type of adsorbed PC. As very limited studies have focused their attention on this particular factor, the present review is tasked to discuss the best simulated environment and latest characterization techniques applied to PC analysis. The effect of PC on the biological behavior of targeting NPs engineered with different targeting moieties is further discussed. Ultimately, the recent progresses in manipulation of nano-bio interfaces to achieve the most favorite therapeutic outcome are highlighted.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Nanoparticles / Protein Corona Type of study: Experimental Studies / Prognostic study Language: English Journal: Int J Pharm Year: 2022 Document Type: Article Affiliation country: J.ijpharm.2022.121458

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Nanoparticles / Protein Corona Type of study: Experimental Studies / Prognostic study Language: English Journal: Int J Pharm Year: 2022 Document Type: Article Affiliation country: J.ijpharm.2022.121458