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Lineage-matched versus mismatched influenza B vaccine effectiveness following seasons of marginal influenza B circulation.
Omer, Itay; Rosenberg, Alina; Sefty, Hanna; Pando, Rakefet; Mandelboim, Michal; Mendelson, Ella; Keinan-Boker, Lital; Glatman-Freedman, Aharona.
  • Omer I; School of Public Health, Tel Aviv University Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
  • Rosenberg A; Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel.
  • Sefty H; Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel.
  • Pando R; Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel; Central Virology Laboratory, Sheba Medical Center, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel.
  • Mandelboim M; School of Public Health, Tel Aviv University Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel; Central Virology Laboratory, Sheba Medical Center, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel.
  • Mendelson E; School of Public Health, Tel Aviv University Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel; Central Virology Laboratory, Sheba Medical Center, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel.
  • Keinan-Boker L; Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel; School of Public Health, University of Haifa, Haifa 3498838, Israel.
  • Glatman-Freedman A; School of Public Health, Tel Aviv University Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel; Israel Center for Disease Control, Israel Ministry of Health, Tel Hashomer, Ramat Gan 5265601, Israel. Electronic address: Aharona.freedman@moh.health.gov.il.
Vaccine ; 40(6): 880-885, 2022 02 07.
Article in English | MEDLINE | ID: covidwho-1615720
ABSTRACT

BACKGROUND:

Several countries have recently transitioned from the trivalent inactivated influenza vaccine (TIV) to the quadrivalent inactivated influenza vaccine (QIV) in order to outweigh influenza B vaccine-mismatch. However, few studies thus far evaluated its benefits versus the TIV in a systematic manner. Our objective was to compare the QIV VE with lineage-mismatched TIV VE.

METHODS:

We estimated the 2015-2016, 2017-2018, 2019-2020 end-of season influenza B VE against laboratory-confirmed influenza-like illness (ILI) among community patients, using the test-negative design. VE was estimated for pre-determined age groups and for moving age intervals of 15 years.

RESULTS:

Since 2011-2012 season, alternate seasons in Israel were dominated by influenza B circulation. Compared with the lineage-mismatched TIV used during the 2015-2016 and 2017-2018 seasons, the 2019-2020 QIV showed the highest all-ages VE, with VE estimates of 56.9 (95% CI 30.1 to 73.4), 16.5 (95% CI -22.5 to 43.1) and -25.8 (95% CI -85.3 to 14.6) for the 2019-2020, 2017-2018 and 2015-2016 seasons, respectively. The 2019-2020 VE point estimated were the highest for the 0.5-4, 5-17 and 18-44 years age groups and for more 15-year age intervals as compared to the other seasons.

CONCLUSIONS:

Our results support the rapid transition from the TIV to the QIV.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human Type of study: Experimental Studies / Observational study / Randomized controlled trials / Systematic review/Meta Analysis Topics: Vaccines Limits: Adolescent / Humans Language: English Journal: Vaccine Year: 2022 Document Type: Article Affiliation country: J.vaccine.2021.12.056

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human Type of study: Experimental Studies / Observational study / Randomized controlled trials / Systematic review/Meta Analysis Topics: Vaccines Limits: Adolescent / Humans Language: English Journal: Vaccine Year: 2022 Document Type: Article Affiliation country: J.vaccine.2021.12.056