Anti-SARS-CoV-2 Inhibitory Profile of New Quinoline Compounds in Cell Culture-Based Infection Models

ABSTRACT

A new anti-SARS-CoV-2 compound, developed in this joint study, is shown in front of SARS-CoV-2 viruses. The ongoing pandemic of human SARS-CoV-2 infections (COVID-19) creates a high demand for antiviral drug development. The shown quinoline?morpholine hybrid and other new quinoline-based compounds were synthesized and investigated for their in vitro activity against SARS-CoV-2. They exerted an anti-SARS-CoV-2 activity similar to or stronger than that of the reference drug. More information can be found in the Research Article by M. Marschall, S.?B. Tsogoeva et?al. (DOI 10.1002/chem.202103861).