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The relationship between obesity classifications and outcomes in COVID-19 infection in New York
Obesity ; 29(SUPPL 2):178, 2021.
Article in English | EMBASE | ID: covidwho-1616044
ABSTRACT

Background:

Despite its high prevalence, published data on COVID-19 infection in obese subjects remains limited. When compared to early-onset diabetes, chronic obstructive pulmonary disease (COPD), advanced age, hypertension (HTN), immunosuppression, and chronic kidney disease (CKD), obesity was the only comorbidity that conferred an increased risk of death exclusively for COVID-19 compared to non-COVID- 19 patients. Any degree of obesity has been associated with poor prognosis in patients with COVID-19 and the risk of mechanical ventilation (MV) is the greatest in patients with BMI > 35 kg/m2, independent of age, diabetes, and hypertension. The aim of our study is to examine the association between various degrees of obesity and the clinical outcomes of patients with COVID-19 infection.

Methods:

This is a retrospective multicenter cohort study of adult patients with a BMI ≥30 kg/m2 presenting to six hospitals in the New York metropolitan region between March 7 and June 7, 2020, with COVID-19 infection. The clinical outcome assessed included hospitalization, in-hospital mortality, intensive care unit (ICU) admission, and MV. Outcomes were compared using a multivariate Cox regression model and Propensity Score matching model.

Results:

The study population comprised 9,991 patients, of whom 53.43% were obese (BMI ≥30 kg/m2). Higher comorbidity burdens, including HTN, Diabetes, CKD, and smoking, were noted in those with Class I and II obesity, relative to Class III obesity (44.54% & 38.00% vs. 22.94%). Obesity increases the risk for in-hospital mortality and intubation across all BMI ranges. Individuals with a BMI ≥ 30 were observed to have the highest risk of ICU admissions (OR 1.29;1.2-1.48;p < 0.001). There were higher rates of in-hospital mortality among obese patients across all BMI [BMI ≥ 30 (OR 1.23;1.09-1.40, p < 0.001);BMI ≥ 35 (OR 1.48;1.28-1.70, p < 0.001);BMI ≥ 40 (OR 1.81;1.55-2.13, p < 0.001).

Conclusions:

Obesity is an independent risk factor for increased mortality in those with COVID-19 infection. Data from this study supports and further expands the existing knowledge on the relationship between obesity and COVID-19 infection. Clinicians must focus on early prevention and management of obesity.
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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Obesity Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Language: English Journal: Obesity Year: 2021 Document Type: Article