Mechanisms of the Effects of Short-Term Inhalations of Xe and O2 Gas Mixture in the Rehabilitation of Post-COVID Ventilation Failure.
Bull Exp Biol Med
; 172(3): 364-367, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1616180
ABSTRACT
The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O2 gas mixture relieved manifestations of ventilation insufficiency and increased SpO2 and pneumatization of the terminal parts of the lungs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oxygen
/
Respiratory Insufficiency
/
Respiratory Therapy
/
Xenon
/
COVID-19
Type of study:
Case report
/
Etiology study
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
/
Europa
Language:
English
Journal:
Bull Exp Biol Med
Year:
2022
Document Type:
Article
Affiliation country:
S10517-022-05393-7
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