Premorbid vulnerability and disease severity impact on Long-COVID cognitive impairment.
Aging Clin Exp Res
; 34(1): 257-260, 2022 Jan.
Article
in English
| MEDLINE | ID: covidwho-1616314
ABSTRACT
BACKGROUND:
Cognitive deficits have been increasingly reported as possible long-term manifestations after SARS-CoV-2 infection.AIMS:
In this study we aimed at evaluating the factors associated with cognitive deficits 6 months after hospitalization for Coronavirus Disease 2019 (COVID-19).METHODS:
One hundred and six patients, discharged from a pneumology COVID-19 unit between March 1 and May 30 2020, accepted to be evaluated at 6 months according to an extensive neurological protocol, including the Montreal Cognitive Assessment (MoCA).RESULTS:
Abnormal MoCA scores at 6 months follow-up were associated with higher pre-hospitalization National Health System (NHS) score (Duca et al. in Emerg Med Pract 221-2, 2020) (OR 1.27; 95% CI 1.05-1.6; p = 0.029) and more severe pulmonary disease expressed by the Brescia-COVID Respiratory Severity Scale (Duca et al. in Emerg Med Pract 221-2, 2020) (BCRSS > 1OR 4.73; 95% CI 1.53-14.63; p = 0.003) during the acute phase of the disease.DISCUSSION:
This longitudinal study showed that the severity of COVID-19, indicated by BCRSS, and a complex score given by age and premorbid medical conditions, expressed by NHS, play a major role in modulating the long-term cognitive consequences of COVID-19 disease.CONCLUSIONS:
These findings indicate that the association of age and premorbid factors might identify people at risk for long-term neurological consequences of COVID-19 disease, thus deserving longer and proper follow-up.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cognitive Dysfunction
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Aging Clin Exp Res
Journal subject:
Geriatrics
Year:
2022
Document Type:
Article
Affiliation country:
S40520-021-02042-3
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