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The future of dry powder inhaled therapy: Promising or discouraging for systemic disorders?
Ye, Yuqing; Ma, Ying; Zhu, Jesse.
  • Ye Y; University of Western Ontario, 1151 Richmond Street, London N6A 3K7, Canada; Ningbo Inhale Pharma, 2260 Yongjiang Avenue, Ningbo National High-Tech Zone, Ningbo 315000, China.
  • Ma Y; University of Western Ontario, 1151 Richmond Street, London N6A 3K7, Canada; Ningbo Inhale Pharma, 2260 Yongjiang Avenue, Ningbo National High-Tech Zone, Ningbo 315000, China.
  • Zhu J; University of Western Ontario, 1151 Richmond Street, London N6A 3K7, Canada. Electronic address: jzhu@uwo.ca.
Int J Pharm ; 614: 121457, 2022 Feb 25.
Article in English | MEDLINE | ID: covidwho-1616526
ABSTRACT
Dry powder inhalation therapy has been shown to be an effective method for treating respiratory diseases like asthma, Chronic Obstructive Pulmonary Diseases and Cystic Fibrosis. It has also been widely accepted and used in clinical practices. Such success has led to great interest in inhaled therapy on treating systemic diseases in the past two decades. The current coronavirus (COVID-19) pandemic also has increased such interest and is triggering more potential applications of dry powder inhalation therapy in vaccines and antivirus drugs. Would the inhaled dry powder therapy on systemic disorders be as encouraging as expected? This paper reviews the marketed and in-development dry powder inhaler (DPI) products on the treatment of systemic diseases, their status in clinical trials, as well as the potential for COVID-19 treatment. The advancements and unmet problems on DPI systems are also summarized. With countless attempts behind and more challenges ahead, it is believed that the dry powder inhaled therapy for the treatment of systemic disorders still holds great potential and promise.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Int J Pharm Year: 2022 Document Type: Article Affiliation country: J.ijpharm.2022.121457

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Int J Pharm Year: 2022 Document Type: Article Affiliation country: J.ijpharm.2022.121457