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Case series of HIV SARS-CoV-2 co-infection in Chinese adults.
Ng, Rita Wai-Yin; Wong, Chun-Kwok; Lui, Grace Chung-Yan; Tso, Eugene Yuk-Keung; Chen, Zigui; Tsang, Owen Tak-Yin; Boon, Siaw Shi; Lai, Christopher Koon-Chi; Fung, Kitty Sau-Chun; Yeung, Apple Chung-Man; Ho, Wendy Ching-Sze; Hui, David Shu-Cheong; Chan, Paul Kay-Sheung; Chan, Jacky Man-Chun.
  • Ng RW; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Wong CK; Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Lui GC; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Tso EY; Department of Medicine and Geriatrics, United Christian Hospital, Hospital Authority, Hong Kong Special Administrative Region, China.
  • Chen Z; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Tsang OT; Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.
  • Boon SS; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Lai CK; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Fung KS; Department of Pathology, United Christian Hospital, Hospital Authority, Hong Kong Special Administrative Region, China.
  • Yeung AC; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Ho WC; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
  • Hui DS; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Chan PK; Stanley Ho Center for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
  • Chan JM; Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, 1/F Clinical Sciences Building, Shatin, N.T. Hong Kong Special Administrative Region, China.
J Clin Virol Plus ; 2(1): 100062, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1616571
ABSTRACT

Objectives:

Little is known whether differences exist in virus shedding, immune and inflammatory response related to SARS-CoV-2 in people living with human immunodeficiency virus (PLWH). We assessed viral RNA and cytokine profiles of HIV and SARS-CoV-2 coinfection in Hong Kong.

Methods:

PLWH hospitalized with SARS-CoV-2 infection in Hong Kong were included, compared with age-matched and disease severity-matched SARS-CoV-2 infected controls (ratio of 15) from February 1st 2020 to July 31st 2020. SARS-CoV-2 infection was confirmed by public health laboratory and virus concentration was quantified by an in-house real-time reverse transcription-quantitative polymerase chain reaction. A panel of cytokines and chemokines were performed.

Results:

HIV patients had a similar respiratory shedding profile compared to controls. Duration of faecal shedding of patient A, B, C and D were at least 9, 10, 33, and 11 days, respectively. HIV patients had lower plasma levels of IL-10 and NT-pro-BNP. All 4 PLWH cases showed seroconversion to SARS-CoV-2 with anti-SARS-CoV-2 S antibodies detected in serum collected between day 18 and 30 after symptom onset.

Conclusions:

PLWH behaves similarly with HIV-negative controls in respiratory viral load, but with decrease in IL-10 and NT-proBNP. PLWH may have a lower risk of immunostimulatory effect due to lower IL-10.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: J Clin Virol Plus Year: 2022 Document Type: Article Affiliation country: J.jcvp.2022.100062

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: J Clin Virol Plus Year: 2022 Document Type: Article Affiliation country: J.jcvp.2022.100062