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Humoral immune response to COVID-19 vaccines in people with secondary progressive multiple sclerosis treated with siponimod.
Krbot Skoric, Magdalena; Rogic, Dunja; Lapic, Ivana; Segulja, Dragana; Habek, Mario.
  • Krbot Skoric M; Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia; Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia.
  • Rogic D; Clinical Institute for Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia. Electronic address: predstojnik.lab@kbc-zagreb.hr.
  • Lapic I; Clinical Institute for Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia. Electronic address: ilapic@kbc-zagreb.hr.
  • Segulja D; Clinical Institute for Laboratory Diagnostics, University Hospital Center Zagreb, Zagreb, Croatia. Electronic address: dsegulja@kbc-zagreb.hr.
  • Habek M; Department of Neurology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia. Electronic address: mhabek@mef.hr.
Mult Scler Relat Disord ; 57: 103435, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1616671
ABSTRACT

OBJECTIVE:

The aim of this study is to determine a development of humoral response after COVID-19 vaccination in persons with secondary progressive multiple sclerosis (pwSPMS) on siponimod, compared to healthy controls (HC).

METHODS:

In 13 pwSPMS taking siponimod and 11 HC, testing for SARS-CoV2 antibodies was performed after vaccination against COVID-19.

RESULTS:

pwSPMS taking siponimod had a significantly lower titer of SARS-CoV2 antibodies compared to healthy controls (19.4 (0-250) vs. 250 (250), p>0.001). Two (15.4%) pwSPMS on siponimod had unmeasurable titers of SARS-CoV2-2 antibodies, while all HC had positive titers.

CONCLUSION:

Although the results of this study are limited by a small sample size, results have consistently shown low titers of SARS-CoV-2 IgG after COVID-19 vaccinations in pwSPMS on siponimod.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Multiple Sclerosis, Chronic Progressive / COVID-19 / Multiple Sclerosis Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article Affiliation country: J.msard.2021.103435

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Multiple Sclerosis, Chronic Progressive / COVID-19 / Multiple Sclerosis Topics: Vaccines Limits: Humans Language: English Journal: Mult Scler Relat Disord Year: 2022 Document Type: Article Affiliation country: J.msard.2021.103435