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Robust and durable serological response following pediatric SARS-CoV-2 infection.
Renk, Hanna; Dulovic, Alex; Seidel, Alina; Becker, Matthias; Fabricius, Dorit; Zernickel, Maria; Junker, Daniel; Groß, Rüdiger; Müller, Janis; Hilger, Alexander; Bode, Sebastian F N; Fritsch, Linus; Frieh, Pauline; Haddad, Anneke; Görne, Tessa; Remppis, Jonathan; Ganzemueller, Tina; Dietz, Andrea; Huzly, Daniela; Hengel, Hartmut; Kaier, Klaus; Weber, Susanne; Jacobsen, Eva-Maria; Kaiser, Philipp D; Traenkle, Bjoern; Rothbauer, Ulrich; Stich, Maximilian; Tönshoff, Burkhard; Hoffmann, Georg F; Müller, Barbara; Ludwig, Carolin; Jahrsdörfer, Bernd; Schrezenmeier, Hubert; Peter, Andreas; Hörber, Sebastian; Iftner, Thomas; Münch, Jan; Stamminger, Thomas; Groß, Hans-Jürgen; Wolkewitz, Martin; Engel, Corinna; Liu, Weimin; Rizzi, Marta; Hahn, Beatrice H; Henneke, Philipp; Franz, Axel R; Debatin, Klaus-Michael; Schneiderhan-Marra, Nicole; Janda, Ales; Elling, Roland.
  • Renk H; University Children's Hospital Tübingen, Tübingen, Germany.
  • Dulovic A; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
  • Seidel A; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Becker M; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
  • Fabricius D; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany.
  • Zernickel M; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany.
  • Junker D; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
  • Groß R; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Müller J; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Hilger A; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Bode SFN; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany.
  • Fritsch L; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Frieh P; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Haddad A; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Görne T; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Remppis J; University Children's Hospital Tübingen, Tübingen, Germany.
  • Ganzemueller T; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
  • Dietz A; Institute of Virology, Ulm University Medical Center, Ulm, Germany.
  • Huzly D; Institute of Virology, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Hengel H; Institute of Virology, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Kaier K; Institute of Medical Biometry and Statistics, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Weber S; Institute of Medical Biometry and Statistics, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Jacobsen EM; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany.
  • Kaiser PD; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
  • Traenkle B; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
  • Rothbauer U; NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
  • Stich M; Department of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Tönshoff B; Department of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Hoffmann GF; Department of Pediatrics I, University Children's Hospital Heidelberg, Heidelberg, Germany.
  • Müller B; Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.
  • Ludwig C; Institute of Transfusion Medicine, Ulm University, Ulm, Germany.
  • Jahrsdörfer B; Institute for Clinical Transfusion Medicine and Immunogenetics, Ulm, Germany.
  • Schrezenmeier H; German Red Cross Blood Transfusion Service, Baden-Württemberg-Hessen, Germany.
  • Peter A; Institute of Transfusion Medicine, Ulm University, Ulm, Germany.
  • Hörber S; Institute for Clinical Transfusion Medicine and Immunogenetics, Ulm, Germany.
  • Iftner T; German Red Cross Blood Transfusion Service, Baden-Württemberg-Hessen, Germany.
  • Münch J; Institute of Transfusion Medicine, Ulm University, Ulm, Germany.
  • Stamminger T; Institute for Clinical Transfusion Medicine and Immunogenetics, Ulm, Germany.
  • Groß HJ; German Red Cross Blood Transfusion Service, Baden-Württemberg-Hessen, Germany.
  • Wolkewitz M; Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, Tübingen, Germany.
  • Engel C; Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tübingen, Tübingen, Germany.
  • Liu W; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
  • Rizzi M; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
  • Hahn BH; Institute of Virology, Ulm University Medical Center, Ulm, Germany.
  • Henneke P; Institute of Clinical Chemistry, Ulm University, Ulm, Germany.
  • Franz AR; Institute of Medical Biometry and Statistics, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Debatin KM; University Children's Hospital Tübingen, Tübingen, Germany.
  • Schneiderhan-Marra N; Center for Pediatric Clinical Studies, University Hospital Tübingen, Tübingen, Germany.
  • Janda A; Department of Microbiology and Department of Medicine, University of Pennsylvania, Philadelphia, USA.
  • Elling R; Department of Rheumatology and Clinical Immunology, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nat Commun ; 13(1): 128, 2022 01 10.
Article in English | MEDLINE | ID: covidwho-1616978
ABSTRACT
The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. Neutralization against wild type SARS-CoV-2 and the Delta VOC are analysed in a pseudotyped virus assay. Children, compared to adults, are five times more likely to be asymptomatic, and have higher specific antibody levels which persist longer (96.2% versus 82.9% still seropositive 11-12 months post infection). Of note, symptomatic and asymptomatic infections induce similar humoral responses in all age groups. SARS-CoV-2 infection occurs independent of HCoV serostatus. Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Immunity, Humoral / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Experimental Studies / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-021-27595-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antibodies, Neutralizing / Immunity, Humoral / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Experimental Studies / Randomized controlled trials Topics: Long Covid / Vaccines / Variants Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-021-27595-9