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Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive older adults.
Romero-Olmedo, Addi J; Schulz, Axel Ronald; Hochstätter, Svenja; Das Gupta, Dennis; Virta, Iiris; Hirseland, Heike; Staudenraus, Daniel; Camara, Bärbel; Münch, Carina; Hefter, Véronique; Sapre, Siddhesh; Krähling, Verena; Müller-Kräuter, Helena; Widera, Marek; Mei, Henrik E; Keller, Christian; Lohoff, Michael.
  • Romero-Olmedo AJ; Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Schulz AR; Deutsches Rheumaforschungszentrum Berlin, Leibniz Institute, Berlin, Germany.
  • Hochstätter S; Institute of Virology, Philipps-University, Marburg, Germany.
  • Das Gupta D; Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Virta I; Deutsches Rheumaforschungszentrum Berlin, Leibniz Institute, Berlin, Germany.
  • Hirseland H; Deutsches Rheumaforschungszentrum Berlin, Leibniz Institute, Berlin, Germany.
  • Staudenraus D; Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Camara B; Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany.
  • Münch C; Institute of Virology, Philipps-University, Marburg, Germany.
  • Hefter V; Institute of Virology, Philipps-University, Marburg, Germany.
  • Sapre S; Institute of Virology, Philipps-University, Marburg, Germany.
  • Krähling V; Institute of Virology, Philipps-University, Marburg, Germany.
  • Müller-Kräuter H; Institute of Virology, Philipps-University, Marburg, Germany.
  • Widera M; Institute of Medical Virology, University Hospital, Goethe University, Frankfurt, Germany.
  • Mei HE; Deutsches Rheumaforschungszentrum Berlin, Leibniz Institute, Berlin, Germany.
  • Keller C; Institute of Virology, Philipps-University, Marburg, Germany.
  • Lohoff M; Institute of Medical Microbiology and Hospital Hygiene, Philipps-University Marburg, Marburg, Germany. lohoff@med.uni-marburg.de.
Nat Microbiol ; 7(2): 195-199, 2022 02.
Article in English | MEDLINE | ID: covidwho-1616988
ABSTRACT
Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (>80 years old, n = 51) and a younger control group (20-53 years old, n = 46) after receiving two doses of BNT162b2. We found that responses in older adults were generally lower, and we identified 10% low-/non-responders. After receiving a third vaccination with BNT162b2, 4 out of 5 low-/non-responders showed antibody and T-cell responses similar to those of responders after two vaccinations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunity, Humoral / Immunogenicity, Vaccine / SARS-CoV-2 / COVID-19 / BNT162 Vaccine / Immunity, Cellular / Antibodies, Viral Type of study: Experimental Studies Topics: Vaccines Limits: Adult / Humans / Middle aged / Young adult Language: English Journal: Nat Microbiol Year: 2022 Document Type: Article Affiliation country: S41564-021-01046-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunity, Humoral / Immunogenicity, Vaccine / SARS-CoV-2 / COVID-19 / BNT162 Vaccine / Immunity, Cellular / Antibodies, Viral Type of study: Experimental Studies Topics: Vaccines Limits: Adult / Humans / Middle aged / Young adult Language: English Journal: Nat Microbiol Year: 2022 Document Type: Article Affiliation country: S41564-021-01046-z