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Persistently high hepatitis C rates in haemodialysis patients in Brazil [a systematic review and meta-analysis].
Niquini, Roberta Pereira; Corrêa da Mota, Jurema; Bastos, Leonardo Soares; da Costa Moreira Barbosa, Diego; Falcão, Juliane da Silva; Palmieri, Paloma; Martins, Patrícia; Melo Villar, Livia; Bastos, Francisco I.
  • Niquini RP; Federal Institute of Education, Science, and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.
  • Corrêa da Mota J; Institute of Scientific and Technological Communication and Information in Health, Oswaldo Cruz Foundation (ICICT-FIOCRUZ), Biblioteca de Manguinhos suite 229, Av. Brasil 4365, Rio de Janeiro, 21045-900, Brazil.
  • Bastos LS; Program for Scientific Computing, Oswaldo Cruz Foundation (PROCC-FIOCRUZ), Rio de Janeiro, Brazil.
  • da Costa Moreira Barbosa D; Federal Institute of Education, Science, and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.
  • Falcão JDS; Federal Institute of Education, Science, and Technology of Rio de Janeiro (IFRJ), Rio de Janeiro, Brazil.
  • Palmieri P; Institute of Scientific and Technological Communication and Information in Health, Oswaldo Cruz Foundation (ICICT-FIOCRUZ), Biblioteca de Manguinhos suite 229, Av. Brasil 4365, Rio de Janeiro, 21045-900, Brazil.
  • Martins P; Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil.
  • Melo Villar L; Laboratory of Viral Hepatitis, Oswaldo Cruz Institute, Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil.
  • Bastos FI; Institute of Scientific and Technological Communication and Information in Health, Oswaldo Cruz Foundation (ICICT-FIOCRUZ), Biblioteca de Manguinhos suite 229, Av. Brasil 4365, Rio de Janeiro, 21045-900, Brazil. francisco.inacio.bastos@hotmail.com.
Sci Rep ; 12(1): 330, 2022 01 10.
Article in English | MEDLINE | ID: covidwho-1617001
ABSTRACT
We conducted a systematic review and meta-analysis of studies assessing HCV infection rates in haemodialysis patients in Brazil (Prospero CRD #42021275068). We included studies on patients under haemodialysis, comprising both convenience samples and exhaustive information from selected services. Patients underwent HCV serological testing with or without confirmation by HCV RNA PCR. Exclusion criteria were the following absence of primary empirical information and studies without information on their respective settings, study year, accurate infection rates, or full specification of diagnostic tests. Studies with samples ≤ 30 and serial assessments with repeated information were also excluded. Reference databases included PubMed, LILACS, Scopus, and Web of Science for the period 1989-2019. A systematic review was carried out, followed by two independent meta-analyses (i) studies with data on HCV prevalence and (ii) studies with a confirmatory PCR (i.e., active infection), respectively. A comprehensive set of different methods and procedures were used forest plots and respective statistics, polynomial regression, meta-regression, subgroup influence, quality assessment, and trim-and-fill analysis. 29 studies and 11,290 individuals were assessed. The average time patients were in haemodialysis varied from 23.5 to 56.3 months. Prevalence of HCV infection was highly heterogeneous, with a pronounced decrease from 1992 to 2001, followed by a plateau and a slight decrease in recent years. The summary measure for HCV prevalence was 34% (95% CI 26-43%) for studies implemented before 2001. For studies implemented after 2001, the corresponding summary measure was 11% (95% CI 8-15%). Estimates for prevalence of active HCV infection were also highly heterogeneous. There was a marked decline from 1996 to 2001, followed by a plateau and a slight increase after 2010. The summary measure for active HCV infection was 19% (95% CI 15-25%) in studies carried out before 2001. For studies implemented after 2001, the corresponding summary measure was 9% (95% CI 6-13%). Heterogeneity was pervasive, but different analyses helped to identify its underlying sources. Besides the year each study was conducted, the findings differed markedly between geographic regions and were heavily influenced by the size of the studies and publication biases. Our systematic review and meta-analysis documented a substantial decline in HCV prevalence among Brazilian haemodialysis patients from 1992 to 2015. CKD should be targeted with specific interventions to prevent HCV infection, and if prevention fails, prompt diagnosis and treatment. Although the goal of HCV elimination by 2030 in Brazil remains elusive, it is necessary to adopt measures to achieve micro-elimination and to launch initiatives towards targeted interventions to curb the spread of HCV in people with CKD, among other high-risk groups. This is of particular concern in the context of a protracted COVID-19 pandemic and a major economic and political crisis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Dialysis / Hepatitis C / Hepacivirus / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-021-03961-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Dialysis / Hepatitis C / Hepacivirus / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-021-03961-x