Analysis of Immune Escape Variants from Antibody-Based Therapeutics against COVID-19: A Systematic Review
International journal of molecular sciences
; 23(1), 2021.
Article
in English
| EuropePMC | ID: covidwho-1619211
ABSTRACT
The accelerated SARS-CoV-2 evolution under selective pressure by massive deployment of neutralizing antibody-based therapeutics is a concern with potentially severe implications for public health. We review here reports of documented immune escape after treatment with monoclonal antibodies and COVID-19-convalescent plasma (CCP). While the former is mainly associated with specific single amino acid mutations at residues within the receptor-binding domain (e.g., E484K/Q, Q493R, and S494P), a few cases of immune evasion after CCP were associated with recurrent deletions within the N-terminal domain of the spike protein (e.g., ΔHV69-70, ΔLGVY141-144 and ΔAL243-244). The continuous genomic monitoring of non-responders is needed to better understand immune escape frequencies and the fitness of emerging variants.
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Collection:
Databases of international organizations
Database:
EuropePMC
Type of study:
Reviews
/
Systematic review/Meta Analysis
Topics:
Variants
Language:
English
Journal:
International journal of molecular sciences
Year:
2021
Document Type:
Article
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