Stem Cell Therapy: A Potential Therapeutic Modality against COVID-19

ABSTRACT

Coronavirus Disease 2019 caused by the Severe Acute Respiratory Syndrome Coronavirus 2 has completely crippled the health and economic sectors across the globe and turned out to be a major threat to human population. The potential role of virus has been considered as an originating cause of tissue injury by disrupting the renin-angiotensin system. However, hyperactive function of immune system also leads to inexorable tissue injury through cytokine storms. Therefore, improved therapeutic interventions have been devised by modulation of the response of immune system. Apart from current ongoing treatments efficacy and safety profile is still a big challenge. MSCs mostly isolated from human bone marrow (BM), in addition to umbilical cord (UC) and adipose tissue (AT) has a great potential for multi-potential differentiation and self-renewal. This manuscript aims to summarize the potential therapeutic applications of stem cell derived therapy with biomedical application in terms of immune-mediated pathophysiological conditions with associated challenges and future advancement.