[Prevalence of laboratory markers of human respiratory viruses in monkeys of Adler primate center].
Vopr Virusol
; 66(6): 425-433, 2022 01 08.
Article
in Russian
| MEDLINE | ID: covidwho-1620062
ABSTRACT
INTRODUCTION:
The relevance of studying the circulation of human respiratory viruses among laboratory primates is associated with the need to test vaccines and antiviral drugs against these infections on monkeys.The aim of this work was to study the prevalence of serological and molecular markers of human respiratory viral infections in laboratory primates born at the Adler Primate Center and in imported monkeys. MATERIAL ANDMETHODS:
Blood serum samples (n = 1971) and lung autopsy material (n = 26) were obtained from different monkey species. These samples were tested for the presence of serological markers of measles, parainfluenza (PI) types 1, 2, 3, influenza A and B, respiratory syncytial (RS) and adenovirus infections using enzyme immunoassay (ELISA). Detection of RS virus, metapneumovirus, PI virus types 1-4, rhinovirus, coronavirus, and adenoviruses B, C, E and bocavirus nucleic acids in this material was performed by reverse transcription polymerase chain reaction (RT-PCR). RESULTS ANDDISCUSSION:
The overall prevalence of antibodies (Abs) among all monkeys was low and amounted 11.3% (95% CI 9.2-13.7%, n = 811) for measles virus, 8.9% (95% CI 6.2-12.2%, n = 381) for PI type 3 virus, 2.5% (95% CI 0.8-5.6%, n = 204) for PI type 1 virus, and 7.7% (95% CI 3.8-13.7%, n = 130) for adenoviruses. When testing 26 autopsy lung samples from monkeys of different species that died from pneumonia, 2 samples from Anubis baboons (Papio аnubis) were positive for of parainfluenza virus type 3 RNA.CONCLUSION:
Our data suggest the importance of the strict adherence to the terms of quarantine and mandatory testing of monkey sera for the presence of IgM antibodies to the measles virus that indicate the recent infection. The role of PI virus type 3 in the pathology of the respiratory tract in Anubis baboons has been established.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Tract Infections
/
Haplorhini
/
Monkey Diseases
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Animals
/
Humans
/
Infant
Country/Region as subject:
Asia
/
Europa
Language:
Russian
Journal:
Vopr Virusol
Year:
2022
Document Type:
Article
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