MYC Expression Is Associated With p53 Expression and TP53 Aberration and Predicts Poor Overall Survival in Acute Lymphoblastic Leukemia/Lymphoma.
Am J Clin Pathol
; 157(1): 119-129, 2022 Jan 06.
Article
in English
| MEDLINE | ID: covidwho-1621542
ABSTRACT
OBJECTIVES:
We evaluated MYC and p53 expression, TP53 aberration, their relationship, and their impact on overall survival (OS) in acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL).METHODS:
We identified 173 patients with ALL and LBL, including 12 cases of mixed-phenotype acute leukemia, 8 cases of therapy-related B-cell ALL (B-ALL), 119 cases of B-ALL, and 34 cases of T-cell ALL/LBL diagnosed from 2003 to 2019. We retrospectively assessed p53 and MYC expression by immunohistochemistry of bone marrow and correlated MYC expression with p53 expression and TP53 aberration.RESULTS:
Expression of p53 and MYC was present in 11.5% and 27.7% of ALL/LBL cases (n = 20 and n = 48), respectively. MYC expression was significantly correlated with p53 expression and TP53 aberration (P = .002 and P = .03), and p53 expression and MYC expression had an adverse impact on OS in patients with ALL/LBL (P < .05). MYC and p53 dual expression as well as combined MYC expression and TP53 aberration had a negative impact on OS in patients with ALL/LBL.CONCLUSIONS:
MYC expression is correlated with p53 overexpression, TP53 aberration, and poor OS in patients with ALL/LBL.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tumor Suppressor Protein p53
/
Proto-Oncogene Proteins c-myc
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Am J Clin Pathol
Year:
2022
Document Type:
Article
Affiliation country:
Ajcp
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