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Immune Immunomodulation in Coronavirus Disease 2019 (COVID-19): Strategic Considerations for Personalized Therapeutic Intervention.
Hall, Mark W; Joshi, Ila; Leal, Luis; Ooi, Eng Eong.
  • Hall MW; Division of Critical Care, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.
  • Joshi I; Partner Therapeutics, Lexington, Massachusetts, USA.
  • Leal L; Partner Therapeutics, Lexington, Massachusetts, USA.
  • Ooi EE; Duke-National University of Singapore Medical School, Singapore.
Clin Infect Dis ; 74(1): 144-148, 2022 01 07.
Article in English | MEDLINE | ID: covidwho-1621566
Semantic information from SemMedBD (by NLM)
1. Immunoregulation ASSOCIATED_WITH COVID-19
Subject
Immunoregulation
Predicate
ASSOCIATED_WITH
Object
COVID-19
2. Immune response CAUSES Alveolar damage
Subject
Immune response
Predicate
CAUSES
Object
Alveolar damage
3. Single organ dysfunction MANIFESTATION_OF Wound Healing
Subject
Single organ dysfunction
Predicate
MANIFESTATION_OF
Object
Wound Healing
4. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Immunoregulation PROCESS_OF Patients
Subject
Immunoregulation
Predicate
PROCESS_OF
Object
Patients
7. other medicated shampoos in ATC TREATS Critical Illness
Subject
other medicated shampoos in ATC
Predicate
TREATS
Object
Critical Illness
8. COVID-19 CAUSES Critical Illness
Subject
COVID-19
Predicate
CAUSES
Object
Critical Illness
9. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
10. other medicated shampoos in ATC TREATS Patients
Subject
other medicated shampoos in ATC
Predicate
TREATS
Object
Patients
11. Immunoregulation ASSOCIATED_WITH COVID-19
Subject
Immunoregulation
Predicate
ASSOCIATED_WITH
Object
COVID-19
12. Immune response CAUSES Alveolar damage
Subject
Immune response
Predicate
CAUSES
Object
Alveolar damage
13. Single organ dysfunction MANIFESTATION_OF Wound Healing
Subject
Single organ dysfunction
Predicate
MANIFESTATION_OF
Object
Wound Healing
14. Immune response PROCESS_OF Patients
Subject
Immune response
Predicate
PROCESS_OF
Object
Patients
15. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
16. Immunoregulation PROCESS_OF Patients
Subject
Immunoregulation
Predicate
PROCESS_OF
Object
Patients
17. other medicated shampoos in ATC TREATS Critical Illness
Subject
other medicated shampoos in ATC
Predicate
TREATS
Object
Critical Illness
18. COVID-19 CAUSES Critical Illness
Subject
COVID-19
Predicate
CAUSES
Object
Critical Illness
19. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
20. other medicated shampoos in ATC TREATS Patients
Subject
other medicated shampoos in ATC
Predicate
TREATS
Object
Patients
ABSTRACT
We are learning that the host response to severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2) infection is complex and highly dynamic. Effective initial host defense in the lung is associated with mild symptoms and disease resolution. Viral evasion of the immune response can lead to refractory alveolar damage, ineffective lung repair mechanisms, and systemic inflammation with associated organ dysfunction. The immune response in these patients is highly variable and can include moderate to severe systemic inflammation and/or marked systemic immune suppression. There is unlikely to be a "one size fits all" approach to immunomodulation in patients with coronavirus disease 2019 (COVID-19). We believe that a personalized, immunophenotype-driven approach to immunomodulation that may include anticytokine therapy in carefully selected patients and immunostimulatory therapies in others is the shortest path to success in the study and treatment of patients with critical illness due to COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunomodulation / Precision Medicine / COVID-19 Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

Full text: Available Collection: International databases Database: MEDLINE Main subject: Immunomodulation / Precision Medicine / COVID-19 Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid