Coronaviral RNA-methyltransferases: function, structure and inhibition.
Nucleic Acids Res
; 50(2): 635-650, 2022 01 25.
Article
in English
| MEDLINE | ID: covidwho-1621653
ABSTRACT
Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for the stability of viral RNA and, most importantly, for the evasion of innate immune system. Non-capped RNA is recognized by innate immunity which leads to its degradation and the activation of antiviral immunity. As a result, both coronaviral MTases are in the center of scientific scrutiny. Recently, X-ray and cryo-EM structures of both enzymes were solved even in complex with other parts of the viral replication complex. High-throughput screening as well as structure-guided inhibitor design have led to the discovery of their potent inhibitors. Here, we critically summarize the tremendous advancement of the coronaviral MTase field since the beginning of COVID pandemic.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Coronavirus
/
Methyltransferases
Limits:
Humans
Language:
English
Journal:
Nucleic Acids Res
Year:
2022
Document Type:
Article
Affiliation country:
Nar
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